Conception, élaboration et caractérisation de matériaux bioactifs |
| |
Authors: | M-C Durrieu |
| |
Institution: | Université Victor-Segalen Bordeaux-2, Inserm, U577, 146, rue Léo-Saignat, Case 45, 33076 Bordeaux cedex, France |
| |
Abstract: | One promising strategy to control the interactions between biomaterial surfaces and attaching cells involves grafting of adhesion peptides as RGD peptides (R: arginine; G: glycine; D: aspartic acid) to materials on which protein adsorption, which mediates unspecific cell adhesion, is essentially suppressed. This review gives an overview of RGD modified materials, that have been used for cell adhesion, and provides information about technical aspects of RGD immobilization on materials. The impacts of RGD peptide surface density, spatial arrangement as well as integrin affinity and selectivity on cell responses like adhesion and migration are discussed. We have tried to relate one of numerous scientifics adventures initiated by Charles Baquey within our laboratory. This review is dedicated to him for his enthusiasm in the development of project and for his wish of always leading of a professional blooming of his students. |
| |
Keywords: | Mots clé s: Peptide RGD Fonctionnalisation Modification de surface Attachement cellulaire Inté grinesRGD peptide Functionalisation Surface treatment Cellular attachement Integrin |
本文献已被 ScienceDirect 等数据库收录! |
|