Green synthesis and biological evaluation of some new benzothiazolo [2,3-b] quinazolin-1-ones as anticancer agents

The simple, multicomponent, water-mediated synthesis of benzothiazolo [2,3-b] quinazolin-1-ones were carried out from aminobenzthiazoles, cyclic β diketone, and aromatic aldehydes. The simplicity, easy work up, short reaction time, and use of environmentally benign water as a solvent are some advantages of this proposed method. The newly synthesized compounds were evaluated for cytotoxicity against a panel of human cancer cell lines (U-937, Hep-2, vero, and MCF-7). Among the synthesized compounds, the compounds 4a and 4d showed higher anticancer activity. The result of DNA fragmentation analysis showed that the compound 4d induced dose-dependent apoptosis. This preliminary study encouraged us to consider the compounds 4a and 4d as interesting leads for further optimization.