Combined effects of CYP1A1 MspI and GSTM1 genetic polymorphisms on risk of lung cancer: an updated meta-analysis |
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| Authors: | Wen Li Li-Qiang Song Jian Tan |
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| Affiliation: | 1. Department of Thoracic Surgery, General Hospital of Beijing Military Command, 5 Nan Men Cang Road, Dong Si Shi Tiao Street, Beijing, 100700, China
2. Department of Respiratory Medicine, The Forth Military Medical University Xi Jing Hospital, Xi’an, 710032, China
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| Abstract: | Genetic polymorphisms of cytochrome P450 1A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) genes might contribute to the variability in individual susceptibility to lung cancer, but the reported results from individual studies are not always consistent. We therefore conducted a meta-analysis to systematically estimate the associations between polymorphisms of these two genes and risk of lung cancer. Twenty-one studies with 8,926 subjects were finally enrolled into this study. Meta-analysis was performed by RevMan 5.2. Odds ratio (OR) and its 95 % confidence interval (CI) were calculated to evaluate the susceptibility to lung cancer. Compared with the wild-type homozygous genotype, significantly elevated risk of lung cancer were associated with variant CYP1A1 MspI (m1/m2?+?m2/m2 vs. m1/m1: OR?=?1.27, 95 % CI?=?1.12–1.43, P?P?P?
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