| 之江菌素的毒性实验 |
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| 引用本文： | 施跃峰 黄文彩. 之江菌素的毒性实验[J]. 中国抗生素杂志, 1998, 23(5): 383-385 |
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| 作者姓名： | 施跃峰 黄文彩 |
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| 作者单位： | 浙江省农业科学院微生物研究所 |
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| 基金项目： | 国家“八五”重点攻关项目 |
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| 摘 要： | 之江菌素对ＩＣＲ小鼠灌胃，ＬＤ５０为１１５３．８ｍｇ／ｋｇ，属低毒物质。致畸致突变试验阴性。亚慢毒性试验表明，大鼠饲喂含之江菌素４００ｐｐｍ的饲料连续２８ｄ，对生长发育、饲料利用率、血液及生化指标、病理组织学观察均无明显不良影响
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| 关 键 词： | 之江菌素 急性毒性 亚慢毒性 诱变性 致畸性 |
Toxicity evaluation of zhijangmycin |
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| Shi Yuefeng Huang Wencai,Xia Zhanen and Sang Jinlong. Toxicity evaluation of zhijangmycin[J]. Chinese Journal of Antibiotics, 1998, 23(5): 383-385 |
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| Authors: | Shi Yuefeng Huang Wencai Xia Zhanen Sang Jinlong |
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| Abstract: | The LD 50 value of zhijiangmycin was 1153.8mg/kg (po). The studies on mutage nicity and teratogenicity gave negative results. In subacute toxicity studies, rats were given food containing 200, 400, 800 ppm zhijiangmycin for 28 days. The animal praxis, body weight, hemato logical parameters as well as pathological observations of the dosage groups of 200 and 400ppm were not significantly affected. |
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| Keywords: | Zhijiangmycin Acute toxicity Subacute toxicity Mutagenicity Teratogenicity |
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