High concentrations of plasma brain-derived neurotrophic factor in methamphetamine users |
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Authors: | Kim Dai-Jin Roh Sungwon Kim Yujung Yoon Su-Jung Lee Hae-Kook Han Chang-Su Kim Yong-Ku |
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Affiliation: | Department of Psychiatry, College of Medicine, Korea University Ansan Hospital, Kyunggi Province, Seoul, Korea. |
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Abstract: | Methamphetamine is a highly addictive drug that has a neurotoxic effect on the brain. A growing body of evidence suggests that brain-derived neurotrophic factor (BDNF) is associated with addictive behavior. The present study investigated the changes in plasma BDNF concentration that were induced by chronic methamphetamine use. Using an enzyme-linked immunosorbent assay (ELISA), we measured peripheral BDNF levels in methamphetamine users and in a control group. The plasma BDNF concentrations of methamphetamine users were significantly higher compared with those of controls (2536.3 pg/ml versus 1352.6 pg/ml). This finding suggests that BDNF plays some role in the neurotoxicity of methamphetamine. |
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