| 槲皮素对血小板聚集和胞浆游离钙的影响(英文) |
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| 引用本文： | 肖东,顾振纶,白建平,汪钟.槲皮素对血小板聚集和胞浆游离钙的影响(英文)[J].中国药理学报(英文版),1995(3). |
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| 作者姓名： | 肖东 顾振纶 白建平 汪钟 |
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| 作者单位： | 苏州医学院药理学教研室，苏州医学院药理学教研室，大同医学专科学校药理学教研室，中国医学科学院药理学教研室 苏州 215007 中国，苏州 215007 中国，大同 037008 中国，北京 100005 中国 |
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| 摘 要： | 目的:研究槲皮素对凝血酶诱导的血小板聚集和胞浆游离钙浓度的影响及钙对槲皮素的血小板聚集抑制效应的作用。方法:用荧光钙离子指示剂观察槲皮素对血小板胞浆游离钙的影响.结果:槲皮素明显抑制凝血酶诱导的血小板聚集和游离钙的升高.IC_(50)和95％可信区间分别为146.2(92.4～231.3)和78.5(49.5—124.4)μmol·L~(-1).槲皮素对血小板的抑制作用可被钙翻转.槲皮素对凝血酶诱导的钙释放无影响.结论:抑制钙内流是槲皮素抑制血小板聚集和Ca~(2 )]_i升高的机制.
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| 关 键 词： | 槲皮素 凝血酶 血小板聚集 钙 |
Effects of quercetin on aggregation and intracellular free calcium of platelets |
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| XIAO Dong,GU Zhen-Lun.Effects of quercetin on aggregation and intracellular free calcium of platelets[J].Acta Pharmacologica Sinica,1995(3). |
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| Authors: | XIAO Dong GU Zhen-Lun |
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| Abstract: | AIM:To study the effects of Que on the in-traplatelet free calcium concentration and the effects of calcium on the inhibition of platelet aggregation by Que. METHODS: Using Quin-2 fluorescence technique. RESULTS: Que inhibited the platelet aggregation and the rise of Ca2 ]i induced by thrombin in platelets. The values of IC50 and 95 % confidence interval were 146. 2 (92- 4 - 231. 3) and 78.5 (49.5-124.4)umol.L-1, respectively. The inhibitory effects of Que on platelet aggregation induced by thrombin were reduced by adding calcium to the medium, and Que had no effect on thrombin-induced internal Ca2 release from dense tubular system. CONCLUSION: The inhibitory effects of-Que on aggregation and the rise of Ca2 ]; in platelets was mainly due to an inhibition of Ca2 influx. |
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| Keywords: | quercetin thrombin platelet aggregation calcium |
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