| The relationship between tumor necrosis factor-a gene polymorphisms and acute severe pancreatitis |
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| 作者姓名： | 张佃良 黎介寿 江志伟 于宝军 唐星明 李维勤 |
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| 作者单位： | Department of General Surgery，Affiliated Hospital，Qingdao University Medical College，Qingdao 266003，China，Department of General Surgery，Jinling Hospital，School of Medicine，Nanjing University，Nanjing 210093，China，Department of General Surgery，Jinling Hospital，School of Medicine，Nanjing University，Nanjing 210093，China，Department of General Surgery，Jinling Hospital，School of Medicine，Nanjing University，Nanjing 210093，China，Department of General Surgery，Jinling Hospital，School of Medicine，Nanjing University，Nanjing 210093，China，Department of General Surgery，Jinling Hospital，School of Medicine，Nanjing University，Nanjing 210093，China |
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| 摘 要： | Objective To investigate the relationship between the presence of the TNF2 allele and plasma concentrations of tumor necrosis factor-α (TNFα) and soluble TNF receptor (sTNF-R) with the development of acute severe pancreatitis (ASP) and severe sepsis.Methods Genomic DNA was prepared from peripheral blood leukocytes. The TNF1 and TNF2 biallelic polymorphisms were identified by analyzing Ncol-digested DNA fragments obtained from PCR products. Plasma levels of TNFa and sTNF-R were measured by EASIA.Results The overall TNF2 allele frequency in ASP patients was comparable to that found in healthy volunteers (29. 2% vs. 29. 3% , P>0. 05). Severe sepsis occurred in 26 of 72 patients. Patients with severe sepsis showed a significantly higher prevalence of TNF2 than those without (46. 2% vs. 19.6%, P<0. 05). Plasma TNFα, sTNF-R Ⅰ, and sTNF-R Ⅱ levels were (36± 31) pg/ml, (5. 4± 3.5) ng/ml, and (11.2±7.8) ng/ml, respectively, in patients with severe sepsis, and (31 ±25) pg/ml, (4.6±3.8) ng/ml, and (8.8
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| 关 键 词： | pancreatitis · tumor necrosis factor· genes ·polymorphism |
The relationship between tumor necrosis factor-a gene polymorphisms and acute severe pancreatitis |
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| ZHANG Dianliang LI Jieshou JIANG Zhiwei YU Baojun TANG Xingming,and LI Weiqin.The relationship between tumor necrosis factor-a gene polymorphisms and acute severe pancreatitis[J].Chinese Medical Journal,2003(11). |
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| Authors: | ZHANG Dianliang LI Jieshou JIANG Zhiwei YU Baojun TANG Xingming and LI Weiqin |
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| Institution: | ZHANG Dianliang LI Jieshou JIANG Zhiwei YU Baojun TANG Xingming
and LI Weiqin Department of General Surgery,Affiliated Hospital,Qingdao University Medical College,Qingdao 266003,China Department of General Surgery,Jinling Hospital,School of Medicine,Nanjing University,Nanjing 210093,China |
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