Die gestörte Gonadotropinsekretion beim Syndrom der polyzystischen Ovarien (PCOS) und Erklärungsmodelle aus In-vitro-Experimenten

A characteristic of the polycystic ovary syndrome (PCOS) is hyperandrogenemia, that might be due to an increased intraovarian secretion of 17α-hydroxylase and/or a tonically increased LH secretion. Vice versa, hyperandrogenemia and other typical signs of PCOS like insulin resistance and hyperinsulinemia could contribute to LH hypersecretion. We examined how the ovarian androgens testosteron and DHT, the adrenal androgen DHEA, insulin, and IGF-I influence LH secretion in female rat pituitary cells. 48 h of treatment with testosterone and DHT lead to a significant suppression of LH secretion. High concentrations of DHEA (10^?6 M) augmented LH secretion significantly. Cells treated with insulin (10^?9 M) for 24 h showed an increase in GnRH-induced LH secretion. IGF-I caused a significant increase in LH secretion.