| 缬沙坦对高血压及心率变异性影响的研究 |
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| 引用本文： | 陈正贵,马立坚,梅全喜.缬沙坦对高血压及心率变异性影响的研究[J].中国医院用药评价与分析,2006,6(2):113-114. |
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| 作者姓名： | 陈正贵 马立坚 梅全喜 |
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| 作者单位： | 广州中医药大学中山附属医院心内科,中山市,588400 |
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| 摘 要： | 目的:研究缬沙坦对高血压心率变异性的影响。方法:选择80例原发性高血压患者服用缬沙坦,分别在治疗前与治疗14周后进行动态心电图(DCG)及心率变异性(HRV)检查,并与对照组(40例)进行比较。结果:治疗后连续R-R间期标准差(SDNN),相邻R-R均方差(RMSSD),相邻R-R间期大于50ms百分数(PNN50)、高频功率(HF)值均明显上升;低频功率与高频功率比值(LF/HF)显著降低(P<0.01),结论:原发性高血压患者存在HRV下降,而缬沙坦在降压的同时,可提高HRV,改善自主神经功能失调。
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| 关 键 词： | 缬沙坦 高血压 心率变异性 |
| 文章编号： | 1672-2124(2006)02-0113-02 |
| 修稿时间： | 2006年2月15日 |
The Effect of Valsartan on Primary Hypertension and Heart Rate Variablity |
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| CHEN Zhenggui,MA Lijian,MEI Quanxi.The Effect of Valsartan on Primary Hypertension and Heart Rate Variablity[J].Evaluation and Analysis of Drug-Use in Hospital of China,2006,6(2):113-114. |
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| Authors: | CHEN Zhenggui MA Lijian MEI Quanxi |
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| Abstract: | OBJECTIVE:To observe the effect of valsartan on primary hypertension and heart rate variability(HRV).METHODS:80 cases with primary hypertension were given valsartan ,they received DCG and HRV examination before treatment and after treatment for 14 weeks respectively.They were compared with control group(40 cases).RESULTS:Standard deviation of normal-to-normal intervals(SDNN),rate of mean square deviation of successive R-R intervals(RMSSD),the percentage of R-R intervals>50ms(PNN50) and high frequency(HF) all obviously increased after treatment;The ratio between low frequency and high frequency(LF/HF) obviously decreased(P<0.01).CONCLUSION:Decreasing of HRV can occur in the patients with primary hypertension.Valsartan can reduce blood pressure,meanwhile,it can also increase HRV,thereby improving functional disorder of autonomic nerve. |
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| Keywords: | valsartan primary hypertension heart rate variability |
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