| 双氯灭痛控释微丸的制备与释药的研究 |
| |
| 引用本文： | 蒋大义,宁德俄,董淳,常翠,杨宏图,贾孟良. 双氯灭痛控释微丸的制备与释药的研究[J]. 中国药房, 2004, 15(9): 542-544 |
| |
| 作者姓名： | 蒋大义 宁德俄 董淳 常翠 杨宏图 贾孟良 |
| |
| 作者单位： | 深圳市人民医院药学部,深圳市,518020 |
| |
| 摘 要： | 目的 :制备双氯灭痛控释微丸并研究其释放机理。方法 :用单因素实验方法考察了包衣液中溶媒系统的组成、膜材的浓度、致孔剂和增塑剂对药物释放的影响。结果 :膜材浓度增加、水比例增大 ,释药速度加快 ;PVPK30 浓度增加 ,释药速度有所加快。这些因素与包衣厚度共同决定衣膜的控释能力。结论 :本制剂属于包衣骨架控释微丸 ,随着包衣厚度的改变 ,释放机理有所不同。
|
| 关 键 词： | 双氯灭痛 控释微丸 释药机制 |
| 文章编号： | 1001-0408(2004)09-0542-03 |
| 修稿时间： | 2004-01-05 |
Preparation of Diclofenac Sodium Controlled Release Pellets and Study on the Release Behaviour |
| |
| JIANG Dayi,NING Dee,DONG Chun,CHANG Cui,YANG Hongtu,JIA Mengliang. Preparation of Diclofenac Sodium Controlled Release Pellets and Study on the Release Behaviour[J]. China Pharmacy, 2004, 15(9): 542-544 |
| |
| Authors: | JIANG Dayi NING Dee DONG Chun CHANG Cui YANG Hongtu JIA Mengliang |
| |
| Abstract: | OBJECTIVE:To prepare diclofenac sodium controlled release pellets and investigate the mechanism of reˉlease.METHODS:Single-factor method was used to investigate the influence of the composition of solvent system in coating solution,the concentration of coating material,porogenic agent and plastifier on the release rate of drug.RESULTS:When the concentration of coating material and the proportion of water increased,the release rate of pellets was increased;the release rate was further increased with PVP K30 added.CONCLUSION:The pellets belongs to the matrix-coating pellets,and the release mechanism varies with the change of coating thickness. |
| |
| Keywords: | diclofenac sodium controlled release pellets release mechanism |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
