| IL-2基因转导对卵巢癌细胞化疗药物敏感性的影响 |
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| 引用本文： | 张震宇,郎景和. IL-2基因转导对卵巢癌细胞化疗药物敏感性的影响[J]. 现代妇产科进展, 2002, 11(3): 171-172 |
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| 作者姓名： | 张震宇 郎景和 |
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| 作者单位： | 1. 首都医科大学附属北京朝阳医院妇产科,北京,100020
2. 中国医学科学院协和医科大学协和医院妇产科 |
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| 摘 要： | 目的:探讨IL-2基因转导能否改变卵巢癌细胞对化疗药物的敏感性。方法:用MTT法测定导入人IL-2基因的卵巢癌细胞对化学治疗药物顺铂、阿霉素、泰素及足叶乙甙治疗的敏感性及IC_50,以导入新霉素基因的卵巢癌细胞系及野生型卵巢癌细胞系为对照。结果:IL-2基因转移使SKOV3细胞对上述化疗药物治疗的敏感性有所提高,但仅对VP-16治疗敏感性的提高差异有显著性（P<0.05）。结论:IL-2基因导入SKOV3细胞没有降低其对实验药物治疗的敏感性。
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| 关 键 词： | 卵巢肿瘤 白细胞介素-2基因 药物疗法,基因转导 |
| 文章编号： | 1004-7379(2002)03-0171-02 |
| 修稿时间： | 2001-12-06 |
Effect of human interleukin 2 gene transfer on the chemotherapeutic sensitivity of ovarian cancer cell line SKOV3 |
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| Zhang Zhenyu ,Lang Jinghe .. Effect of human interleukin 2 gene transfer on the chemotherapeutic sensitivity of ovarian cancer cell line SKOV3[J]. Current Advances In Obstetrics and Gynecology, 2002, 11(3): 171-172 |
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| Authors: | Zhang Zhenyu Lang Jinghe . |
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| Affiliation: | Zhang Zhenyu 1,Lang Jinghe 2. 1. Department of Obstetrics and Gynecology,Beijing Chaoyang Hospital of Capital Medical University,Beijing 100020, 2. Department of Obstertrics and Gynecology,Peking Union Medical College Hospital,Chinese Academy of Medi |
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| Abstract: | ve:To evaluate the effect of human interleukin 2 (IL-2) gene transfer on the chemotherapeutic sensitivity of ovarian cancer cell line SKOV3. Methods: MTT reduction assay was engaged to evaluate IL-2 cDNA modified SKOV3 cell to cisplatin, adrimycin, taxol and VP-16, as Neo gene modified and the wide type SKOV3 cell for control. IC50 was calculated. Results: IL-2 gene modified SKOV3 cell was more sensitive to VP-16 treatment (P < 0.05). Conclusion: IL-2 gene modification does not depress the sensitivity of ovarian cancer cell to the chemotherapeutic treatment. |
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| Keywords: | Ovarian neoplasms Interleukin-2 gene Drug therapy Gene transfer |
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