低分子量肝素作用机制及临床应用研究进展

肝素是一种广泛应用于临床的抗凝血药物,现已发现肝素的生物活性主要来源于其与数百种不同蛋白质的相互作用,因此,肝素除了具有抗凝作用外,还具有较强的抗炎、抗肿瘤、抗病毒、促进伤口愈合、抗贫血等药理特性.随着对肝素的深入研究,低分子量肝素被发现,与普通肝素相比,低分子量肝素具有较长的半衰期、更好的生物利用度,更少发生出血、过...

Research progress on action mechanism and clinical application of low molecular weight heparin

Heparin is an anticoagulant drug widely used in clinic.It has been found that the biological activity of heparin mainly comes from its interaction with hundreds of different proteins.Therefore,besides anticoagulation,heparin also has strong pharmacological properties such as anti-inflammation,anti-tumor,anti-virus,promoting wound healing,and anti-anemia.With the in-depth study of heparin,low molecular weight heparin (LMWH) was discovered.Compared with ordinary heparin,LMWH has longer half-life and better bioavailability,and less risk of bleeding,allergic reaction and adverse reactions such as thrombocytopenia induced by heparin.In this paper,the mechanism of action and clinical application of LMWH were reviewed.