结直肠癌肝转移预后评分系统的现状及临床应用

结直肠癌是中国第二常见的恶性肿瘤,其中约50%的患者最终会发生肝转移。有效的全身治疗和积极包括手术在内的局部治疗,是提升结直肠癌肝转移患者疗效的关键。肝切除术后复发是导致结直肠癌肝转移患者死亡的主要原因,不同复发风险的患者治疗选择也有所不同,因此建立有效的结直肠癌肝转移预后评分系统,以指导其个体化治疗至关重要。临床危险评分(CRS)是目前结直肠癌肝转移患者应用最广泛的预后评分系统。其他预后评分系统还包括肿瘤负荷评分(TBS)、GAME评分、CERR评分等。预后评分系统的不断完善可以更好地帮助临床医生预测结直肠癌肝转移病人预后,对高危患者采取更积极的干预手段,合理有效地延长患者生命。

Current status and clinical application of the prognostic scoring system for colorectal liver metastasis

Colorectal cancer is the second most common malignant tumor in China,and about 50%of patients will have liver metastases.Effective systemic treatment and active local treatment including surgery are the key to improving the efficacy of patients with colorectal liver metastasis.Recurrence after hepatectomy is the main cause of death in patients with colorectal liver metastasis.The treatment options for patients with different recurrence risks are also different.Therefore,it is very important to establish an effective prognostic scoring system for colorectal liver metastasis to guide its individualized treatment.Clinical Risk Score(CRS)is currently the most widely used prognostic scoring system for patients with colorectal liver metastasis.Other prognostic scoring systems include Tumor Burden Score(TBS),Genetic And Morphological Evaluation(GAME)score,and Comprehensive Evaluation of Relapse Risk(CERR)score.The continuous improvement of the prognosis scoring system can better help clinicians predict the prognosis of patients with colorectal liver metastasis,and adopt more active intervention methods for high-risk patients to reasonably and effectively prolong the lives of patients.