缬沙坦联合氨氯地平治疗慢性肾脏病合并肾性高血压的效果

目的 探讨缬沙坦联合氨氯地平治疗慢性肾脏病合并肾性高血压的疗效及安全性.方法 选取2017年5月至2018年12月于我院进行治疗的慢性肾脏病合并肾性高血压患者,采用随机数字表法分为对照组(n=55)和观察组(n=55).对照组行氨氯地平治疗方案,观察组行缬沙坦联合氨氯地平治疗方案.比较两组患者治疗效果、血压变化、肾功能...

Effect of valsartan combined with amlodipine in the treatment of chronic kidney disease complicated with renal hypertension

Objective To investigate the efficacy and safety of valsartan combined with amlodipine in the treatment of patients with chronic kidney disease complicated with renal hypertension.Methods Patients with chronic kidney disease complicated with renal hypertension who were treated in our hospital from May 2017 to December 2018 were selected and divided into the observation group(n=55) and the control group(n=55) according to the random number table method.The control group was treated with amlodipine,while the observation group was treated with valsartan combined with amlodipine.The therapeutic effect,changes in blood pressure,renal function and drug safety were compared between the two groups.Results The total effective rate of 90.91% in the observation group was higher than 72.73% in the control group(P<0.05).Before treatment,there was no significant difference in SBP and DBP between the two groups(P>0.05).After treatment,SBP and DBP decreased in both group(P<0.05),and the decrease degree of SBP and DBP in the observation group was more significant(P<0.05).Before treatment,there was no significant difference in renal function indexes between the two groups(P>0.05).After treatment,the level of GFR,24-hour urinary protein quantity,Scr,BUN and other indexes were improved in both groups (P<0.05),more significantly in the observation group(P<0.05).No serious adverse reactions occurred during the treatment in the two groups,and the drug was very safe for the treatment.Conclusion Valsartan combined with amlodipine for the treatment of patients with chronic kidney disease complicated with renal hypertension can effectively improve the blood pressure and renal function,and with good drug safety,which has clinical significance for further discussion.