Oligopeptides excreted in the urine of healthy humans and of patients with nephrotic syndrome |
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| Authors: | W Lutz K Markiewicz L Klyszejko-Stefanowicz |
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| Affiliation: | 1. School of Geography and Ocean Science, Nanjing University, Nanjing 210023, China;2. Key Laboratory of the Coastal Zone Exploitation and Protection, Ministry of Natural Resources, Nanjing 210023, China;3. School of Environment Engineering, Nanjing Institute of Technology, Nanjing 211167, China;4. NJIT Research Center, The Key Laboratory of Carbon Neutrality and Territory Optimization, Ministry of Natural Resources, Nanjing 211167, China;5. International Joint Laboratory of Green & Low Carbon Development, Nanjing 211167, China;1. Hochschule für Gesundheit (University of Applied Sciences), Department of Applied Health Sciences, Division of Physiotherapy, Gesundheitscampus 6-8, 44801 Bochum, Germany;2. Deakin University, Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Geelong, Victoria, Australia;3. Gerontology Research Center and Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland;4. Imaging@Olympic Park, Melbourne, Victoria, Australia;5. Low Back Research Team, College of Science, Health & Engineering, La Trobe University, Bundoora, Victoria, Australia;6. Advance HealthCare, Boronia, Victoria, Australia;7. Division of Physical Medicine and Rehabilitation, Department of Medicine, Bone and Joint Research Laboratory, University of Ottawa, The Ottawa Hospital Research Institute, Canada |
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| Abstract: | The isolation and separation of oligopeptides excreted in the urine is the subject of this investigation.Twelve simple oligopeptides of molecular weight ranging from 500 to 1200 were found in the urine of both healthy persons and patients with nephrotic syndrome. In normal urine, 6 oligopeptides from the group of molecular weight under 500 were found, whereas in patients there were 4 additional oligopeptides. Quantitive evaluation of the separate oligopeptides excreted was carried out on basis of the α-amino nitrogen determination (after hydrolysis).Statistically significant differences (p < 0.01) in the oligopeptides excreted in the urine of healthy persons and patients with nephrotic syndrome was confirmed for only 4 acid oligopeptides of molecular weight in the range of 500 to 1200. |
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