| 涎腺腺样囊性癌SACC-83细胞C-erbB2、PTEN基因表达的研究 |
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| 引用本文： | 刘晓华,张引成,任文豪,曹腾腾,饶国洲. 涎腺腺样囊性癌SACC-83细胞C-erbB2、PTEN基因表达的研究[J]. 口腔医学, 2010, 30(8): 477-480 |
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| 作者姓名： | 刘晓华 张引成 任文豪 曹腾腾 饶国洲 |
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| 作者单位： | 1. 西安交通大学口腔医院口腔颌面外科,西安,710004
2. 西安交通大学口腔医院中心实验室,西安,710004 |
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| 摘 要： | 目的 检测涎腺腺样囊性癌SACC-83细胞中C-erbB2基因和PTEN基因的表达,并探讨其相关性。方法 培养SACC-83细胞,采用RT-PCR、免疫组化技术分别检测C-erbB2基因和PTEN基因的mRNA、蛋白产物在涎腺腺样囊性癌SACC-83细胞和正常腺体细胞中的表达情况。结果 C-erbB2基因mRNA及蛋白水平在SACC-83细胞中的表达明显高于正常腺体细胞,差异有显著性;PTEN基因在SACC-83细胞及正常腺体细胞中的表达无明显差异。结论 C-erbB2基因在涎腺腺样囊性癌SACC-83细胞中过表达,可能与涎腺腺样囊性癌的发生有关。
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| 关 键 词： | 涎腺腺样囊性癌 C-erbB2 PTEN 基因治疗 |
C-erbB2 and PTEN expressions in salivary gland adenoid cystic carcinoma cell line SACC-83 |
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| LIU Xiao-hua,ZHANG Yin-cheng,REN Wen-hao,CAO Teng-teng,RAO Guo-zhou. C-erbB2 and PTEN expressions in salivary gland adenoid cystic carcinoma cell line SACC-83[J]. Stomatology, 2010, 30(8): 477-480 |
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| Authors: | LIU Xiao-hua ZHANG Yin-cheng REN Wen-hao CAO Teng-teng RAO Guo-zhou |
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| Affiliation: | .(Stomatology Hospital,Xi′an Jiaotong University,Xi′an 710004,China) |
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| Abstract: | Objective To detect the expressions of C-erbB2 and PTEN in salivary gland adenoid cystic carcinoma cell line SACC-83,and study the correlation of them.Methods After we cultured SACC-83 cell,RT-PCR and immunohistochemistry were employed to detect the expressions of C-erbB2 and PTEN in SACC-83 cell and normal salivary gland cell.Results The expression of C-erbB2 in SACC-83 cell was conspicuously higher than that in normal salivary gland cell.But the expressions of PTEN in SACC-83 cell and normal salivary gland cell were not different.Conclusion Our data demonstrated that C-erbB2 gene was overexpressed in salivary gland adenoid cystic carcinoma cell line SACC-83,and it was related to salivary gland adenoid cystic carcinoma genesis. |
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| Keywords: | C-erbB2 PTEN |
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