Development and validation of a HPLC method for the determination of sertraline and three non-chiral related impurities |
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| Authors: | Alessia Ferrarini Angel Luis Huidobro Federica Pellati Coral Barbas |
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| Affiliation: | 1. Facultad de Farmacia, Universidad San Pablo-CEU, Urbanización Montepríncipe, Boadilla del Monte, 28668 Madrid, Spain;2. Department of Pharmaceutical Sciences, University of Modena and Reggio Emilia, Via G. Campi 183, 41100 Modena, Italy |
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| Abstract: | In this study, a screening on reversed-phase stationary phases (including C8, C18, CN, PEG and amide) was carried out in order to obtain an efficient HPLC method for the determination of sertraline and three of its more closely related synthetical and non-chiral impurities, without using ion-pair reagents. The best results in terms of both retention time and resolution of the target analytes were obtained with a Zorbax Bonus-RP column, which contains a polar amide group embedded in a C14 alkyl chain. |
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| Keywords: | HPLC Method optimization Pharmaceuticals Validation |
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