FDG PET显像在判断鼻咽癌放疗后鼻咽病灶复发中的临床价值

目的 探讨脱氧葡萄糖正电子发射断层扫描(FDG PET)在鼻咽癌放射治疗后随诊中的临床价值以及与CT、MRI的互补作用.方法 回顾性分析放射治疗后6～8个月、CT和MRI检查考虑鼻咽病灶复发的6例鼻咽癌患者,随后行FDG PET检查,并均作病理活检.结果 6例CT和MRI提示肿瘤复发的鼻咽癌患者,PET显示其中2例有局灶性FDG代谢明显增高,经病理活检,证实仅2例FDG摄取浓聚的病变为肿瘤复发.结论 与CT和MRI检查相比,FDG PET在鼻咽癌放射治疗后肿瘤复发的定性诊断上具有明显优势,若结合CT或MRI的影像结果分析,取得局部病变的结构与代谢改变复合信息,对后期局部复发病灶的精确适形放射治疗具有重要意义.

Clinical value of FDG PET to detect recurrence of nasopharyngeal carcinoma after radiotherapy

Objective To investigate the clinical value of FDG PET imaging in the follow-up of nasopharyngeal carcinoma after radiotherapy and complementation with CT/MRI.Methods In our prognostic analysis,6 patients with nasopharyngeal carcinoma were considered recurrence by CT and MRI during 6-8 months after radiotherapy.They also underwent FDG PET and biopsy.Results Two of six patients showed significantly increased FDG metabolism that diagnosed recurrence by CT and MRI scans.These were pathologically confirmed.Conclusion FDG PET imaging has an advantage in distinguishing the relapse in the follow-up of post-radiotherapy nasopharyngeal carcinoma patients.PET,CT and MRI is able to give a detail both in morphological and functional changes of disease.They are especially useful in the follow-up or the set-up treatment planning for recurrent nasopharyngeal carcinoma.