Acrylamide: Dermal Exposure Produces Genetic Damage in Male Mouse Germ Cells |
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Authors: | GUTIERREZ-ESPELETA, GUSTAVO A. HUGHES, LORI A. PIEGORSCH, WALTER W. SHELBY, MICHAEL D. GENEROSO, WALDERICO M. |
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Affiliation: | *Biology Division, Oak Ridge National Laboratory P.O. Box 2009, Oak Ridge, Tennessee 37738-8077; National Institute of Environmental Health Sciences Building PO. Box 12233, Research Triangle Park, North Carolina 27709 Received December 11, 1990; accepted August 7, 1991 |
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Abstract: | Acrylamide is used extensively in sewage and wastewater treatmentplants, in the paper and pulp industry, in treatment of potablewater, and in research laboratories for chromatography, electrophoresis,and electron microscopy. Dermal contact is a major route ofhuman exposure. It has been shown that acrylamide is highlyeffective in breaking chromosomes of germ cells of male miceand rats when administered intraperitoneally or orally, resultingboth in the early death of conceptuses and in the transmissionof reciprocal translocations to live-born progeny. It is nowreported that acrylamide is absorbed through the skin of malemice, reaches the germ cells, and induces chromosomal damage.The magnitude of genetic damage appears to be proportional tothe dose administered topically. |
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