L-精氨酸对大鼠蛛网膜下腔出血后一氧化氮含量及脑水肿的影响

目的:探讨一氧化氮(NO)与蛛网膜下腔出血(SAH)后脑水肿的关系和L-精氨酸(L-Arg)的影响。方法:检测假手术组(SO组)、SAH组和SAH+L-Arg组大鼠24 h内局部脑血流量(rCBF)动态变化,并测定不同时间的血清NO水平及脑组织水、Na⁺含量。结果:SAH组术后rCBF迅速而持续低于SO组,血清NO水平明显低于SO组、脑组织水、Na⁺含量显著高于SO组。L-Arg处理后上述异常改变均明显减轻。结论:SAH后血清NO水平下降与脑水肿的产生有关,L-Arg对SAH后脑水肿具有缓解作用。

Effect of L-arginine on nitric oxide and brain edema after subarachnoid hemorrhage in rats

AIM: To investigate the role of nitric oxide in the development of brain edema after subarachnoid hemorrhage(SAH), and the influence of L-arginine on them. METHODS: Noncraniotomy models of SAH in Wistar rats were used and animals were divided into sham-operated group, SAH group and SAH plus L-arginine group. Dynamic changes of regional cerebral blood flow within 24 hours were measured. Serum nitric oxide level, brain water and sodium content at different time points within 24 hours were also detected. RESULTS: Regional cerebral blood flow and serum nitric oxide level at every time point after operation in SAH group were lower than those in sham-operated group, while brain water content and sodium content in the former group were higher than those in the latter group. Above pathological alterations in SAH plus L-arginine group were not so obvious as in SAH group. CONCLUSION: Decrease in serum nitric oxide plays a role in the development of brain edema after SAH, which may be partly reversed by administration of L-arginine.