Glycoglycerolipid analogues active as anti-tumor-promoters: the influence of the anomeric configuration |
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Authors: | Colombo D Compostella F Ronchetti F Scala A Toma L Tokuda H Nishino H |
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Affiliation: | Dipartimento di Chimica e Biochimica Medica, Università di Milano, Via Saldini 50, 20133, Milan, Italy. diego.colombo@unimi.it |
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Abstract: | The in vitro anti-tumor promoting effect of monohexanoates of 2-O-alpha-D-gluco- and galactopyranosyl-sn-glycerol on the 12-O-tetradecanoylphorbol-13-acetate (TPA) induced Epstein-Barr virus early antigen (EBV-EA) activation was evaluated and compared to the potencies of the corresponding beta-anomers. The results show that the inversion of the anomeric configuration from beta to alpha does not seem to significantly influence the activity, which is present, as for the beta-anomers, even at 1x10 mol ratio without any cytotoxicity. |
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Keywords: | glycoglycerolipid analogues cancer chemoprevention Epstein– Barr virus activation test anti-tumor-promoting activity |
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