辛伐他汀对短暂性脑缺血发作患者颈动脉粥样硬化斑块的影响

目的探讨辛伐他汀对短暂性脑缺血发作（TIA）患者颈动脉粥样硬化斑块（AP）的影响。方法将86例明确伴有颈动脉AP的TIA患者随机分为研究组及对照组；研究组口服辛伐他汀及阿斯匹林肠溶片，对照组仅口服阿斯匹林肠溶片；于治疗前、治疗2及8个月后进行颈动脉超声检查，测颈动脉内-中膜厚度（IMT）、AP面积、数量，并观察治疗期间2组患者脑血管病的发生情况。结果与治疗前及对照组比较，研究组治疗8个月后颈动脉IMT变薄及AP面积、数量均明显减少，差异均有统计学意义（P〈0．05），但治疗2个月后上述指标与治疗前比较，差异均无统计学意义（P〉0．05）；治疗8个月后研究组脑血管病的发生率与对照组比较，差异无统计学意义（P〉0．05）。结论较长时间服用辛伐他汀能有效稳定TIA患者的颈动脉AP。

Effect of simvastatin on carotid atherosclerotic plaque in patients with transient ischemic attack

Objective To discuss the relationship between simvastatin and carotid atherosclerotic plaque （AP） in patients with transient ischemic attack. Methods 86 patients with TIA and carotid AP were randomly divided into two groups： Investigation group and control group. Investigation group received simvastatin and aspirin Enteric coated,while the control group received aspirin Enteric-coated only. The intima midia thickness （IMT） of carotid artery, the area of carotid atherosclerosis plaque, and the number of AP were measured before treatment,after 2 and 8 months of treatment respectively. Incidence rate of cerebrovascular event in the two groups were compared in 8 months. Results Compared with before treatment and control group, after 8 months of treatment, the IMT of carotid artery, the area of carotid AP and the number of AP significantly reduced in the investigation group（P〈0. 05）. But those of after 2 months of treatment are not reduced significantly compared with before treatment（P〉0. 05）. There was no significant difference in the incidence rates of cerebrovascular event between the two groups（P〉0. 05）. Conclusions It is shown that the longer utilization of simvastatin can effectively stabilize carotid AP in patients with TIA