输血传播病毒在不同人群中的感染状况及致病性分析

目的探讨TTV在不同人群中的感染状况及其致病性。方法对454例人员,采用微板核酸杂交ELISA法检测TTV;血清酶测定ALT、AST和TBILI。结果454例标本中TTV阳性检出率为5.95%(27/454)。其中在肝病组检出率为3.92%(6/153),分别为肝硬化7.69%(1/13),肝癌0%(0/16),重症慢性乙肝0%(0/22),急性黄疸型乙肝11.11%(1/9),未分型急性黄疸型肝炎0%(0/2),乙肝病毒携带者4.40%(4/91)。在非肝病组检出率为6.89%(21/301),分别为新生儿高胆红素血症0%(0/25),恶性肿瘤9.76%(4/41),献血员11.0%(11/100),体检人员4.44%(6/135)。献血员和体检人员与各种疾病患者的感染率无明显差异(P>0.05);TTV感染者与未感染者的肝功能状况无明显差异(P>0.05);在肝炎患者中,感染TTV者和未感染TTV者的肝功能状况无明显差异(P>0.05)。结论在一般人群和献血员中TTV感染呈“无症状”的“携带状态”,在多种疾病患者中TTV感染无明显加重病情的作用。

The infection and pathogenicity of TT virus among different populations

Objective To detect the infection and pathogenicity of TT virus among different populations.Methods Tests were carried out on TT virus by microplate nucleotide hybridization-ELISA technique and on ALT,AST,TBILT by serum enzymology from 454 cases of people.Results It showed that 5.95%(27/454) of 454 samples were positive for TTV.In the group of the patients with liver diseases,3.92%(6/153) were positive for TTV.Among 153 samples,7.69%(1/13) was positive for liver cirrhosis,0%(0/16) was positive for liver carcinoma,0%(0/22) was positive for chronic hepatitis B gravis,11.11%(1/9) was positive for icteritious acute hepatitis B,0%(0/2) was positive for undifferentiated icteritious acute hepatitis and 4.40%(4/91) were positive for carriers with hepatitis B virus.In the group of the people with non-liver diseases,6.98%(21/301) were positive for TTV.Among 301 samples,0%(0/25) was positive for neonatal hyperbilirubinemia,9.76%(4/41) were positive for the patients with malignant tumor after operations,11.0%(11/100) were positive for blood donors and 4.44%(6/135) were positive for somatoscopy population.The infection rates of TT virus in blood donors and somatoscopy population wasn't remarkably different from that of in the patients with different diseases(P>0.05).The liver function of the patients who had infected TT virus wasn't remarkably different from that of the people who didn't infect TT virus(P>0.05).In hepatitis patients,the liver function of the people who had also infected TT virus wasn't remarkably different from that of the people who didn't infect TT virus(P>0.05).Conclusion The common populations and blood donors who had infected TT virus were in status of carriers.The infection of TT virus didn't aggravate the state of illness of the patients remarkably.So it indicated that TT virus couldn't cause diseases probably and there weren't susceptible population.