Regional localization of two MRX genes to Xq28 (MRX28) and to Xp11.4-Xp22.12 (MRX33) |
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| Authors: | E Holinski-Feder A Golla I Rost H Seidel O Rittinger A Meindl |
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| Institution: | Abteilung Pädiatrische Genetik an der Kinderpoliklinik der Ludwig-Maximilians-Universität München, München, Germany |
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| Abstract: | Two genes responsible for a nonspecific form of X-linked mental retardation (MRX28 and MRX33) were localized by linkage analysis with 40 highly polymorphic DNA markers situated along the entire the X chromosome. In family 1, the gene could be mapped within a 14-cM interval at Xq28, distal to the recombining marker DXS1113 (MRX28). The maximum LOD score was 2.75, with DXS52 at ? = .0. In family 2, the gene was localized within a 30-cM interval at Xp11.4-22.12 between the recombining markers DXS365 and MAOB, including the DMD gene (MRX33). Maximum LOD scores of 2.82 were obtained with markers DMD-STR49, DMD-DysII, CYBB, and DXS1068. © 1996 Wiley-Liss, Inc. |
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| Keywords: | gene localization mental retardation MRX Xq28 Xp11 4-22 12 linkage analysis |
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