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Transgenic mouse model for the fragile X syndrome |
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| Authors: | R. Frank Kooy Rudi D'Hooge Edwin Reyniers Cathy E. Bakker Guy Nagels Kristel De Boulle Katrien Storm Gilbert Clincke Peter P. De Deyn Ben A. Oostra Patrick J. Willems |
| Affiliation: | Departments of Medical Genetics and Neurochemistry and Behaviour, Born-Bunge Foundation, University of Antwerp, Antwerp, Belgium |
| Abstract: | Transgenic fragile X knockout mice have been constructed to provide an animal model to study the physiologic function of the fragile X gene (FMR1) and to gain more insight into the clinical phenotype caused by the absence of the fragile X protein. Initial experiments suggested that the knockout mice show macroorchidism and cognitive and behavioral deficits, abnormalities comparable to those of human fragile X patients. In the present study, we have extended our experiments, and conclude that the Fmr1 knockout mouse is a reliable transgenic model to study the fragile X syndrome. © 1996 Wiley-Liss, Inc. |
| Keywords: | fragile X syndrome Fmr1 knockout mice transgenic animal model spatial learning macroorchidism hyperactivity |