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Functional reorganization induced by endovascular embolization of a cerebral AVM |
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| Authors: | Randolph S. Marshall Lotfi Hacein-Bey William L. Young John Pile-Spellman Sam Das Gerard Perera J. P. Mohr |
| Affiliation: | 1. Department of Radiology, Neurological Institute, Columbia-Presbyterian Medical Center, New York, New York 10032;2. Department of Anesthesiology, Neurological Institute, Columbia-Presbyterian Medical Center, New York, New York 10032 Department of Neurological Surgery, Neurological Institute, Columbia-Presbyterian Medical Center, New York, New York 10032;3. Department of Radiology, Neurological Institute, Columbia-Presbyterian Medical Center, New York, New York 10032 Department of Neurological Surgery, Neurological Institute, Columbia-Presbyterian Medical Center, New York, New York 10032;4. Department of Neurology, Neurological Institute, Columbia-Presbyterian Medical Center, New York, New York 10032 Department of Neurological Surgery, Neurological Institute, Columbia-Presbyterian Medical Center, New York, New York 10032 |
| Abstract: | We mapped motor function in a patient with a cerebral arteriovenous malformation (AVM) before and after treatment with endovascular embolization. Functional activation using technetium-99m-hexamethylpropyleneamine single photon emission tomography (99mTc-HMPAO-SPECT) demonstrated a redistribution of regional cerebral blood flow (rCBF) that correlated with clinical improvement. Intravascular feeding artery pressure measurements, serial angiography, and challenge with a pharmacological vasodilator enabled us to explore possible mechanisms of functional reorganization. © 1996 Wiley-Liss, Inc. |
| Keywords: | arteriovenous malformation motor recovery cerebrovascular disease acetazolamide diaschisis single photon emission tomography cerebral blood flow functional activation |