| Abstract: | The origins of the −28 A→C and frameshift Cd 11 −T (Fs Cd 11 −T) alleles were investigated by β-globin cluster haplotype analysis. These alleles were found in a Mexican mestizo family with β-thalassemia (β-thal). The -28 A→C mutation was described previously in Kurdish Jews linked to the most common haplotype in the world (+−−−−++), the same haplotype observed in this Mexican family. Therefore, it is not possible to assess a new origin of the −28 A→C mutation in our population. The Fs Cd 11 −T allele, not reported to date in any other populations, was linked to the −++−−+− haplotype (sixth in frequency in the world). This haplotype has not been reported in association with any β-thal mutant, suggesting a Mexican origin for the Cd 11 −T mutation. © 1995 Wiley-Liss, Inc. |
