复方氯己定含漱液联合阿昔洛韦治疗儿童疱疹性口腔炎的临床研究

目的 分析复方氯己定含漱液联合阿昔洛韦治疗儿童疱疹性口腔炎的临床疗效。方法 选取2021年1月—2023年7月同济大学附属上海市第四人民医院收治的112例疱疹性口腔炎患儿，按随机数字表法将患儿分为对照组和治疗组，每组各56例。对照组静脉滴注注射用阿昔洛韦，15 mg/kg加入5%葡萄糖注射液中稀释至1 mg/mL后滴注1 h以上，2次/d。治疗组患者在对照组治疗基础上给予复方氯己定含漱液，10 mL/次，含3 min后吐出，2次/d，于早晚刷牙后含漱。两组疗程均为7 d。观察两组的临床疗效、临床表现消失时间，比较治疗前后两组饮食行为问卷（MBQ）、儿童睡眠习惯问卷中文版（CSHQ）评分、全血淋巴细胞数（LYMP#）和血清前白蛋白（PAB）水平变化。结果 治疗后，治疗组总有效率是100.00%，显著高于对照组的89.29%（P＜0.05）。治疗后，治疗组发热、烦躁哭闹、拒食、疼痛流涎、疱疹及溃疡的消失时间均显著短于对照组（P＜0.05）。治疗后，两组MBQ、CSHQ评分均显著降低（P＜0.05）；治疗后，治疗组MBQ、CSHQ评分低于对照组（P＜0.05）。治疗后，两组全血LYMP#均显著降低，而血清PAB水平均显著上升（P＜0.05）；治疗后，治疗组全血LYMP#和血清PAB水平改善优于对照组（P＜0.05）。结论 复方氯己定含漱液联合阿昔洛韦治疗儿童疱疹性口腔炎具有较佳的安全性及疗效，能迅速缓解患儿临床表现，减轻病毒感染程度，促进饮食、睡眠及预后改善。

Clinical study of Compound Gargle Solution Chlorhexidine Giuconaie combined with aciclovir in treatment of herpetic stomatitis in children

Objective To analyze the clinical efficacy of Compound Gargle Solution Chlorhexidine Giuconaie combined with aciclovir in treatment of herpetic stomatitis in children. Methods A total of 112 children with herpetic stomatitis admitted to Shanghai Fourth People’s Hospital Affiliated to Tongji University from January 2021 to July 2023 were selected and divided into control group and treatment group according to random number table method, with 56 cases in each group. Children in control group were iv administered with Aciclovir for injection, 15 mg/kg was added into 5% glucose injection, diluted to 1 mg/mL, and then indribbled for more than 1 h, twice daily. Patients in treatment group were given Compound Gargle Solution Chlorhexidine Giuconaie on the basis of the control group, 10 mL/time, spit out after 3 min, twice daily, and gargle after brushing in the morning and evening. The treatment course of both groups was 7 d. The clinical efficacy and disappearance time of clinical manifestations of two groups were observed, and the scores of Eating Behavior questionnaire (MBQ), Children’s Sleeping Habits Questionnaire (CSHQ), whole blood lymphocyte count (LYmpU #) and serum prealbumin (PAB) were compared between two groups before and after treatment. Results After treatment, the total effective rate in the treatment group was 100.00%, which was significantly higher than 89.29% in control group (P < 0.05). After treatment, the disappearance time of fever, irritability crying, food refusal, sore salivation, herpes and ulcer in the treatment group was significantly shorter than that in control group (P < 0.05). After treatment, MBQ and CSHQ scores were significantly decreased in both groups (P < 0.05). After treatment, MBQ and CSHQ scores in the treatment group were lower than those in the control group (P < 0.05). After treatment, whole blood lympP # was significantly decreased, while serum PAB level was significantly increased in both groups (P < 0.05). After treatment, the whole blood LYmpP # and serum PAB levels in treatment group were better than those in control group (P < 0.05). Conclusion Compound Gargle Solution Chlorhexidine Giuconaie combined with aciclovir has good safety and efficacy in treatment of herpetic stomatitis in children, and can quickly alleviate the clinical manifestations of children, reduce the degree of viral infection, which can promote improvement in diet, sleep, and prognosis.