| 前列腺增生组织中细胞外信号调节蛋白激酶表达的意义 |
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| 引用本文： | 谢庆祥,韩聪祥,林福地.前列腺增生组织中细胞外信号调节蛋白激酶表达的意义[J].中国现代医学杂志,2003,13(4):26-27. |
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| 作者姓名： | 谢庆祥 韩聪祥 林福地 |
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| 作者单位： | 福建省漳州市解放军第175医院泌尿外科,363000 |
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| 基金项目： | 南京军区医院卫生科研基金资助 (99NO2 4) |
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| 摘 要： | 目的：探讨细胞外信号调节蛋白激酶1(ERKl)在良性前列腺增生症(BPH)发病机制中的作用。方法：应用免疫组化方法检测68例BPH和12例正常前列腺(NP)组织中ERKl和增殖细胞核抗原(PCNA)的表达。结果：ERKl主要分布于前列腺上皮细胞，BPH组织中ERKl表达显著高于NP组织(P＜0．05)，而又BPH组织中ERKl表达与PCNA指数密切相关(P＜0.05)。结论：ERKl异常表达在前列腺细胞增殖、增生过程中起着重要作用。
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| 关 键 词： | 前列腺增生 细胞外信号调节蛋白激酶 增殖细胞核抗原 发病机制 多肽生长因子 |
| 修稿时间： | 2002年5月16日 |
EXPRESSION OF EXTRACELLULAR SIGNAL-REGULATED KINASE IN BENIGN PROSTATIC HYPERPLASIA |
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| Xie Qingxiang,Han Congxiang,Lin Fudi.EXPRESSION OF EXTRACELLULAR SIGNAL-REGULATED KINASE IN BENIGN PROSTATIC HYPERPLASIA[J].China Journal of Modern Medicine,2003,13(4):26-27. |
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| Authors: | Xie Qingxiang Han Congxiang Lin Fudi |
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| Institution: | Xie Qingxiang,Han Congxiang,Lin Fudi. Department of Urology,the 175th Hospital of PLA,Zhangzhou 363000$$$$ |
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| Abstract: | Objective:To investigate the role of extracellular signal-regulated kinase 1 (ERK1) in pathogenesis of benign prostatic hyperplasia (BPH). Methods:The immunohistochemical method was adopted to examine expressions of ERK1 and proliferation cell nuclear antigen (PCNA) in 68 cases of BPH specimens and 12 cases of normal prostatic tissues (NP).Results:ERK1 was primarily located in prostatic epithelium. Expressions of ERK1 in BPH were significantly higher than those in NP. There was a close association bewteen ERK1 expression and PCNA index in BPH. Conclusions:Abnormal expression of ERK1 plays an important role in prostatic cell proliferation and hyperplasia. |
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| Keywords: | Prostatic Hyperplasia Extracellular Signal-regulated Kinase Proliferation Cell Nuclear Antigen |
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