| 神经生长因子受体在垂体腺瘤中的表达 |
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| 引用本文： | 张作洪,朱炎昌,雷霆. 神经生长因子受体在垂体腺瘤中的表达[J]. 临床与实验病理学杂志, 2000, 16(1): 28-30 |
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| 作者姓名： | 张作洪 朱炎昌 雷霆 |
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| 作者单位： | 1. 湖北省荆州市第一人民医院神经外科,434000
2. 同济医科大学附属同济医院神经外科,武汉,430030 |
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| 基金项目： | 教育部回国人员启动基金资助项目!教外司留(1997)43 6号 |
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| 摘 要： | 目的：探讨两种神经生长因子（ＮＧＦ）受体（ＴｒＫＡ和ｇｐ７５）在各类垂体腺瘤中的表达。方法：采用免疫细胞化学ＳＡＢＣ法，检测了４４例经病理证实的垂体腺瘤中两种ＮＧＦ受体的表达情况。结果：ＴｒＫＡ在垂体ＰＲＬ分沁腺瘤中的过度表达率６９．２％，而在其它类型垂体腺瘤中的过度表达率为１９．４％，两者比较差异有非常显著性（Ｐ〈０．００５）。ｇｐ７５在垂体ＰＲＬ分泌腺瘤中的过度表达率在４６．２％，而在其它类型
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| 关 键 词： | 垂体肿瘤 受体 神经生长因子 |
| 修稿时间： | 1999-05-05 |
The expression of nerve growth factor receptors in pituitary adenomas |
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| Zhang Zuohong,Zhu Yanchang,Lei Ting. The expression of nerve growth factor receptors in pituitary adenomas[J]. Chinese Journal of Clinical and Experimental Pathology, 2000, 16(1): 28-30 |
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| Authors: | Zhang Zuohong Zhu Yanchang Lei Ting |
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| Abstract: | Purpose To evaluate the expression of two nerve growth factor (NGF) receptors (TrKA and gp75) in each type of pituitary adenomas. Methods Forty four cases of pathologically confirmed pituitary adenomas were examined for the two NGF receptors expression with immunocytochemical SABC method. Resultls Overexpression rate of TrKA was 69 2% in pituitary PRL secreting adenomas and 19 4% in other types of pituitary adenomas. The difference was highly significant ( P< 0 005). Overexpression rate of gp75 was 46 2% in pituitary PRL secreting adenomas and 9 7% in others. The difference was significant ( P< 0 05). Conclusion Two NGF receptors are expressed mainly in pituitary PRL secreting adenomas, and gp75 expression might be associated with the tumoral aggression and the sensitivity to the treatment of dopamine D 2 receptor agonists. |
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| Keywords: | pituitary neoplasms adenoma receptors nerve growth factor prolactin TrKA gp75 immunocytochemistry |
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