| 静脉滴注重组人血管内皮抑素联合动脉灌注化疗治疗晚期恶性肿瘤的临床观察 |
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| 引用本文： | 王革芳,程永德,王咏梅,杜爱民,毛勇,陆海宇,姜程远,陆海洲,王蕾.静脉滴注重组人血管内皮抑素联合动脉灌注化疗治疗晚期恶性肿瘤的临床观察[J].介入放射学杂志,2009,18(4). |
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| 作者姓名： | 王革芳 程永德 王咏梅 杜爱民 毛勇 陆海宇 姜程远 陆海洲 王蕾 |
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| 作者单位： | 解放军第八五医院内一科,上海,200052 |
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| 摘 要： | 目的 探讨静脉滴注重组人血管内皮抑素联合动脉灌注化疗治疗晚期恶性肿瘤的疗效及安全性.方法 选取41例晚期恶性肿瘤患者人组研究,分为治疗组和对照组,均给予相应的肿瘤供血动脉灌注化疗,治疗组在灌注化疗后当天开始给予重组人血管内皮抑素静脉滴注治疗,连用14 d,间隔7 d为1个周期,对照组仅行动脉灌注化疗治疗,于2个治疗周期后比较疗效和生活质量评分,同时比较不良反应.结果 重组人血管内皮抑素治疗组治疗后疾病控制率、K氏评分显著升高,差异有统计学意义(P<0.05);有效率和不良反应与对照组差异无统计学意义(P>0.05).结论 采用静脉滴注重组人血管内皮抑素联合动脉灌注化疗治疗晚期恶性肿瘤,患者的疾病控制率和生活质量有明显的提高,而治疗相关不良反应不大,值得临床推广及进一步研究.
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| 关 键 词： | 重组人血管内皮抑素 动脉灌注化疗 晚期恶性肿瘤 抗肿瘤血管形成 |
Intravenous drip transfusion of recombinant human endostatin combined with arterial infusion chemotherapy for the treatment of advanced carcinomas: a clinical observation |
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| WANG Ge-fang,CHENG Yong-de,WANG Yong-mei,DU Ai-min,MAO Yong,LU Hai-yu,JIANG Cheng-yuan,LU Haizhou,WANG Lei. No.Intravenous drip transfusion of recombinant human endostatin combined with arterial infusion chemotherapy for the treatment of advanced carcinomas: a clinical observation[J].Journal of Interventional Radiology,2009,18(4). |
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| Authors: | WANG Ge-fang CHENG Yong-de WANG Yong-mei DU Ai-min MAO Yong LU Hai-yu JIANG Cheng-yuan LU Haizhou WANG Lei No |
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| Institution: | WANG Ge-fang,CHENG Yong-de,WANG Yong-mei,DU Ai-min,MAO Yong,LU Hai-yu,JIANG Cheng-yuan,LU Haizhou,WANG Lei. No.1 Department of Internal Medicine,No. 85 Hospital of PLA,Shanghai 200052,China |
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| Abstract: | Objective To discuss the clinical effects and the safety of intravenous drip transfusion of recombinant human endostatin combined with arterial infusion chemotherapy for the treatment of advanced carcinomas. Methods Forty-one patients with advanced carcinomas were enrolled in this study. The patients were divided into study group and control group. All patients underwent relevant infusion chemotherapy via the tumor-feeding artery. At the same day when the arterial infusion chemotherapy was completed, patien... |
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| Keywords: | recombinant human endostatin arterial infusion chemotherapy advanced carcinoma anti-neoplastic angiogenesis |
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