PI3K/Akt/mTOR信号通路在骨关节炎中的作用

骨关节炎（OA）是常见的骨关节疾病，是导致疼痛和致残的主要病因，主要影响膝、髋、腕、脊柱等关节。OA发病机制尚不清楚。PI3K/Akt/mTOR信号通路调控细胞的生长、分化、迁移、血管生成和代谢，是体内调节细胞凋亡、自噬的重要通路。最近有研究发现PI3K/Akt/mTOR信号通路参与了OA的发生、发展。笔者查阅相关文献后拟从PI3K/Akt/mTOR信号通路对OA作用机制研究的新进展进行综述，以期为OA的防治提供新思路。

Role of PI3K/Akt/mTOR signaling pathway in osteoarthritis

Osteoarthritis (OA) is the most common form of joint disease, and is the leading cause of pain and disability by affecting knee, hip, wrist, spine and other joints. However, the pathogenesis of osteoarthritis is still unclear. PI3K/Akt/mTOR signaling pathway regulates cell growth, differentiation, and migration, as well as angiogenesis and metabolism, and is also essential for apoptosis and autophagy. Recent studies have found that PI3K/Akt/mTOR signaling pathway is involved in the occurrence and development of osteoarthritis. This paper reviews the research progress on the roles of PI3K/Akt/mTOR signaling pathway in osteoarthritis, aiming to provide novel ideas for the prevention and treatment of osteoarthritis.