| SIRT3/FOXO3通路在肺癌A549细胞放疗抵抗中的作用机制研究 |
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| 引用本文： | 方庆亮,董昌盛,陈荣,龚卿,陆松,宋仁杰,顾香莲,王蕾,顾煜恺. SIRT3/FOXO3通路在肺癌A549细胞放疗抵抗中的作用机制研究[J]. 中国现代医学杂志, 2021, 0(12): 28-34 |
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| 作者姓名： | 方庆亮 董昌盛 陈荣 龚卿 陆松 宋仁杰 顾香莲 王蕾 顾煜恺 |
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| 作者单位： | 1.上海中医药大学附属龙华医院，放疗科，上海 200032;2.上海中医药大学附属龙华医院，中医肿瘤研究所，上海 200032 |
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| 摘 要： | 目的 探讨沉默信息调节因子3(SIRT3)/叉头转录因子O3(FOXO3)通路在肺癌A549细胞放疗抵抗中的作用.方法 体外培养肺癌A549细胞,设置对照组(A549细胞)、放疗组(A549细胞+X射线照射)、SIRT3抑制剂(3-TYP)组(A549细胞+50μmol/L 3-TYP)、X射线+3-TYP组(A549...
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| 关 键 词： | 肺肿瘤 放疗抵抗 沉默信息调节因子3/基因 叉头转录因子3/叉头转录因子类 |
| 收稿时间： | 2020-12-24 |
The role of SIRT3/FOXO3 pathway in radiotherapy resistance of lung cancer A549 cells |
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| Qing-liang Fang,Chang-sheng Dong,Rong Chen,Qing Gong,Song Lu,Ren-jie Song,Xiang-lian Gu,Lei Wang,Yu-kai Gu. The role of SIRT3/FOXO3 pathway in radiotherapy resistance of lung cancer A549 cells[J]. China Journal of Modern Medicine, 2021, 0(12): 28-34 |
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| Authors: | Qing-liang Fang Chang-sheng Dong Rong Chen Qing Gong Song Lu Ren-jie Song Xiang-lian Gu Lei Wang Yu-kai Gu |
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| Affiliation: | 1.Department of Radiotherapy, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China; 2. Cancer Research Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China;2.Department of Radiotherapy, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China; 2. Cancer Research Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China |
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| Abstract: | |
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| Keywords: | sirtuin-3/forkhead box O3 pathway radiotherapy resistance lung cancer A549 cell radiotherapy resistance |
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