Human papillomavirus infection in oral potentially malignant disorders and cancer |
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| Institution: | 1. Division of Virology, National Public Health Institute, Budapest, Hungary;2. Department of Oral Biology and Experimental Dental Research, Faculty of Dentistry, University of Szeged, Szeged, Hungary;3. Department of Otorhinolaryngology and Head-Neck Surgery, Faculty of Medicine, University of Szeged, Szeged, Hungary;4. Department of Oral Surgery, Faculty of Dentistry, University of Szeged, Szeged, Hungary;5. Institute of Clinical Microbiology, University of Szeged, Faculty of Medicine, Szeged, Hungary;6. Hungarian Academy of Sciences, Biological Research Centre, Szeged, Hungary;1. Antiviral Immunity Biotherapy and Vaccine Unit, Institut Pasteur, Paris, France;2. Sorbonne Paris Cité Université Paris Diderot, Paris, France;3. Université Paris Descartes, Imagine Institute, Necker Hospital, Paris, France;4. Centre de Physiopathologie de Toulouse Purpan, Toulouse, France;5. INSERM, U1043, Toulouse, France;6. CNRS, UMR5282, Toulouse, France;7. Université Toulouse III Paul-Sabatier, Toulouse, France;8. Université Paris Diderot, UMR-S728, INSERM, Paris, France;9. Service de Dermatologie, Centre Hospitalier Universitaire, SFR FED 4234, EA 3181, Université de Franche Comté, Besançon, France;10. UMR 1282 INRA-Université François Rabelais, Tours, France;11. Laboratoire d’Immunologie, Hôpital Saint-Louis, Paris, France;12. Service de Dermatologie-Allergologie, Hôpital Tenon, Université Paris VI, AP-HP, Paris, France |
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| Abstract: | Human papillomavirus (HPV) infects keratinocytes in the mucosa or skin, and persistent infection with HPV may lead to premalignant lesions and invasive cancer, especially cervical cancer. It has also been hypothesized that HPV infection is an etiological factor of oral squamous cell carcinoma and oral precancerous disorders such as lichen planus, leukoplakia, and erythroplakia. A high percentage of HPV in oral lesions supports the possible viral contribution, but an association of HPV infection with these lesions remains to be established. The current paper will update the latest progress of HPV infection in several oral potentially malignant disorders and oral squamous cell carcinoma and discuss the impact of HPV infection on the progression of oral potentially malignant disorders. |
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| Keywords: | Human papillomavirus (HPV) Oral potentially malignant disorders Oral squamous cell carcinoma (OSCC) Oral lichen planus Oral leukoplakia |
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