Early bony changes associated with bisphosphonate-related osteonecrosis of the jaws in rats: A longitudinal in vivo study |
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| Institution: | 1. Department of Dentistry, Faculty of Health Sciences, University of Brasília, Campus Universitário Darcy Ribeiro, Asa Norte, Zip Code: 70910-900, Brasília, Brazil;2. Oral Care Center for Inherited Diseases, Faculty of Health Sciences, University of Brasília, Campus Universitário Darcy Ribeiro, Asa Norte, Zip Code: 70910-900, Brasília, Brazil;3. Biology Institute University of Brasília, Campus Universitário Darcy Ribeiro, Asa Norte, Zip Code: 70910-900, Brasília, Brazil;4. Biological Sciences Department, State University of West Paraná, Rua Universitária 2069, Cascavel, Zip Code: 85819-110, Paraná, Brazil;1. São Paulo State University (Unesp) (Head: Prof. W. R. Poi), School of Dentistry, Araçatuba, Rua José Bonifácio 1193, Araçatuba, SP, Brazil;2. School of Dentistry, Sagrado Coração University – USC, Rua Irmã Arminda 10-50, Bauru, SP, Brazil;1. Department of Oral and Maxillofacial Surgery, University Hospital of Erlangen, Glueckstrasse 11, 91054, Erlangen, Germany;2. Department of Oral and Maxillofacial Surgery, Royal Free NHS Trust, Chase Farm Hospital, 127 The Ridgeway, Enfield, Middlesex EN2 8JL, UK;1. Department of Oral and Maxillofacial Surgery, Gaziantep University, Gaziantep, Turkey;2. Department of Pathology, Gaziantep University, Gaziantep, Turkey;3. Department of Physiology Gaziantep University, Gaziantep, Turkey;4. Department of Oral and Maxillofacial Surgery, Gazi University, Ankara, Turkey;1. Division of Restorative Dentistry, Faculty of Dentistry, McGill University, Montreal, QC, Canada;2. Division of Oral and Maxillofacial Surgery, Faculty of Dentistry, McGill University, Montreal, QC, Canada;3. Bone Engineering Labs, Research Institute, McGill University Health Center, Montreal, QC, Canada;4. Department of Medicine and Surgery, Faculty of Medicine, McGill University, Montreal, QC, Canada;5. Department of Dental Materials and Prosthodontics, Faculty of Dentistry of Ribeirão Preto, University of Sao Paulo, Brazil |
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| Abstract: | ObjectiveTo evaluate early bony changes in an animal model of Medication-Related Osteonecrosis of the Jaw (MRONJ) at the side of the local trauma and at the contralateral side, comparing with a control group. Bony changes were evaluated by Microcomputed Tomography (MicroCT) at three times points: at baseline (T0), after drug administration (T1) and after dental extraction (T2).DesignTwo groups were compared: the experimental group in which zoledronic acid (ZA) was administered (17 rats) and the control group (13 rats). Dental extractions of the lower left first molars were performed in all animals. The left side was considered as the supposed affected area in the ZA group, and the right side was considered as the unaffected area. In these areas, the following structural microtomographic bone parameters were calculated: Bone Mineral Density (BMD), Trabecular Thickness (Tb.Th), and Bone Volume Proportion (BV/TV). The comparison of quantitative bone parameters among the different sides and experimental phases of both studied groups were performed by ANOVA-factorial.ResultsNone of the animals of the control group developed MRONJ. In the ZA group, 76% presented bone exposure. From T0 to T1, Tb.Th and BV/TV increased, and in T2, the mean values were higher in ZA group than in the control group. BMD increased throughout the different phases of both groups.ConclusionsStructural bony changes occurred in the ZA group at both mandibular sides before the dental extraction (T1). Tb.Th and BV/TV should be further investigated as potential early bone markers of MRONJ. |
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| Keywords: | Medication-related osteonecrosis of the jaws Zoledronic acid Microcomputed tomography Animal model |
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