Gingival crevicular fluid and plasma oxidative stress markers and TGM-2 levels in chronic periodontitis |
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| Affiliation: | 1. Ege University, School of Dentistry, Department of Periodontology, İzmir, Turkey;2. Adnan Menderes University, School of Dentistry, Department of Periodontology, Aydın, Turkey;3. Institute of Molecular Biomedicine, Comenius University, Bratislava, Slovakia;4. Institute of Clinical and Translational Research, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia;1. ITMO University, 49 Kronverksky Ave., 197101 St. Petersburg, Russia;2. Baltic State Technical University, 190005 St. Petersburg, Russia;3. Special Materials Corp., 194044 St. Petersburg, Russia;4. Peter the Great St. Petersburg Polytechnic University, 195251 St. Petersburg, Russia;1. Kazan Institute of Biochemistry and Biophysics, Kazan Scientific Center, Russian Academy of Sciences, Kazan, Russia;2. Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, Kazan, Russia;3. Kazan State Medical University, Kazan, Russia;4. A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland;5. Department of Neuroscience Imaging and Clinical Sciences, University “G. d''Annunzio” of Chieti-Pescara, Chieti, Italy;6. Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland;1. Assistant Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Istanbul University, Istanbul, Turkey;2. Research Assistant, Department of Oral Implantology, Faculty of Dentistry, Istanbul University, Istanbul, Turkey;3. Assistant Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Istanbul University, Istanbul, Turkey;4. Associate Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Istanbul University, Istanbul, Turkey;1. Materials Center Leoben Forschung GmbH, Roseggerstr. 12, Leoben 8700, Austria;2. Institute for Electron Microscopy and Fine Structure Research, Steyrerg. 17/III, Graz 8010, Austria;3. ams AG, Tobelbader Str. 30, Premstaetten 8141, Austria |
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| Abstract: | ObjectiveThis study was aimed to evaluate the gingival crevicular fluid (GCF) and plasma transglutaminase-2 (TGM-2), total antioxidant capacity (TAC), total oxidant status (TOS), ferric reducing antioxidant power (FRAP) and thiobarbituric acid reactive substances (TBARS) in patients with chronic periodontal disease.Materials and methodsTwenty patients with chronic periodontitis (CP), 20 patients with gingivitis and 20 healthy subjects were enrolled in the study. Clinical periodontal parameters including probing depth, clinical attachment level, plaque index and papillary bleeding index were recorded. GCF and plasma levels of TGM-2, TAC, TOS, TBARS and FRAP were analyzed.ResultsGCF TGM-2 was significantly lower in CP group than in gingivitis patients (P = 0.006). GCF FRAP in CP and gingivitis groups was significantly lower than in healthy subjects (P < 0.001). Plasma FRAP level was lower in gingivitis group when compared to healthy subjects (P = 0.003). There was no significant difference in GCF and plasma TAC, TOS, TBARS and plasma TGM-2 levels among the study groups (P > 0.05). GCF TGM-2 level was positively correlated with GCF TAC and negatively correlated with CAL.ConclusionsDecreased FRAP in GCF and plasma indicating lower antioxidant status of CP patients might suggest the role of oxidative stress in periodontitis. GCF TGM-2 data might suggest that TGM2 is associated with stabilization of the extracellular matrix and wound healing in periodontium rather than gingival inflammation. |
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| Keywords: | Transglutaminase-2 Oxidative stress Gingival crevicular fluid Chronic periodontitis |
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