Gender differences of neuropsychological profiles in cognitively normal older people without amyloid pathology |
| |
| Affiliation: | 1. Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China;2. Department of Respiratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China;3. Institutes of Brain Science, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China;4. Beijing Huilongguan Hospital, Peking University, Beijing, China;1. Sichuan University, China;2. RMIT University, Australia;1. CHU de Bordeaux, INSERM-CHU CIC-P 0005, Service de Neurologie, Bordeaux F-33076, France;2. Université de Bordeaux, Bordeaux F-33076, France;3. Neurocentre Magendie, INSERM U1215, Team Glia-neuron Interactions, Bordeaux F-33077, France |
| |
| Abstract: | ObjectiveTo investigate the impact of sex on cognition among cognitively normal older people without amyloid pathology.MethodsThe study sample consisted of 83 males (mean age 74 years, ranging from 65 to 88 years) and 111 females (mean age 72 years, ranging from 65 to 89 years) who were cognitively normal without amyloid pathology confirmed by Pittsburgh compound B PET scan. We examined the sex discrepancies in cognition using a comprehensive neuropsychological battery.ResultsOur data showed significantly greater advantage for women than men on the tasks of verbal memory and category fluency while better performance of naming in men than women when age, education and depressive symptoms were considered.ConclusionThese findings highlight the importance of considering sex differences in the interpretation of cognitive data which contribute to clinical diagnosis of neurodegenerative disorders, such as Alzheimer's disease. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
