| 结直肠癌患者血清microRNA-335、microRNA-497表达与临床病理特征及预后的关系 |
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| 引用本文： | 聂向荣,武剑磊,武永庆. 结直肠癌患者血清microRNA-335、microRNA-497表达与临床病理特征及预后的关系[J]. 中国现代医学杂志, 2021, 0(11): 7-12 |
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| 作者姓名： | 聂向荣 武剑磊 武永庆 |
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| 作者单位： | 1.邯郸市中心医院,普外三科,河北 武安 056399;2.邯郸市中心医院,邯郸市中心医院 急诊外科,河北 武安 056399;3.邯郸市中心医院,武安市第一人民医院 骨科,河北 武安 056399 |
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| 基金项目： | 河北省2017年度医学科学研究重点课题计划项目（No：20171138） |
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| 摘 要： | 目的 探究结直肠癌患者血清microRNA-335(miR-335)、microRNA-497(miR-497)表达与临床病理特征及预后的关系.方法 选取2013年2月—2014年9月于邯郸市中心医院诊治的99例结直肠癌患者作为结直肠癌组,选择同期在该院体检的99例健康者作为健康组.采用实时荧光定量PCR(qRT-PC...
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| 关 键 词： | 结直肠肿瘤 miR-335 miR-497 临床病理特征 预后 |
| 收稿时间： | 2020-12-12 |
Relationship of serum miR-335 and miR-497 expression with clinicopathological features and prognosis in patients with colorectal cancer |
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| Xiang-rong Nie,Jian-lei Wu,Yong-qing Wu. Relationship of serum miR-335 and miR-497 expression with clinicopathological features and prognosis in patients with colorectal cancer[J]. China Journal of Modern Medicine, 2021, 0(11): 7-12 |
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| Authors: | Xiang-rong Nie Jian-lei Wu Yong-qing Wu |
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| Affiliation: | 1.Third Department of General Surgery, Handan Central Hospital, Handan, Hebei 056001, China; 2. Department of Emergency Surgery, Handan Central Hospital, Handan, Hebei 056001, China; 3. Department of Orthopaedics, Wu''an First People''s Hospital, Wu''an, Hebei 056399, China;2.Third Department of General Surgery, Handan Central Hospital, Handan, Hebei 056001, China; 2. Department of Emergency Surgery, Handan Central Hospital, Handan, Hebei 056001, China; 3. Department of Orthopaedics, Wu''an First People''s Hospital, Wu''an, Hebei 056399, China;3.Third Department of General Surgery, Handan Central Hospital, Handan, Hebei 056001, China; 2. Department of Emergency Surgery, Handan Central Hospital, Handan, Hebei 056001, China; 3. Department of Orthopaedics, Wu''an First People''s Hospital, Wu''an, Hebei 056399, China |
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| Abstract: | Objective To investigate the relationship of serum Microrna-335 (miR-335) and miR-497 expression in colorectal cancer patients with their clinicopathological characteristics and prognosis.Methods From February 2013 to September 2014, 99 colorectal cancer patients who were diagnosed and treated in our hospital were selected as the colorectal cancer group, and 99 healthy patients who underwent physical examination in our hospital during the same period were selected as the healthy group. Fluorescence quantitative PCR was used to detect the expression levels of serum miR-335 and miR-497 in the two groups, and the clinicopathological characteristics of patients with different serum miR-335 and miR-497 expression levels were compared. Kaplan-Meier method was used to analyze the prognosis of patients with different serum miR-335 and miR-497 expression levels.Results The expression levels of serum miR-335 and miR-497 in the colorectal cancer group were lower than those in the healthy group (P < 0.05). The expression level of serum miR-497 in patients with infiltrative depth T1-T2, TNM stage I/II, and without lymph node metastasis were higher than those in patients with infiltrative depth T3-T4, TNM stage III, and with lymph node metastasis (P < 0.05). The expression level of serum miR-335 in patients with TNM stage I/II, Medium and high differentiation were higher than than those in patients with TNM stage III and low differentiation (P < 0.05). 5-year survival rates of colorectal cancer patients with high serum miR-497 expression and high miR-335 expression were higher than those with low serum miR-497 expression and low miR-335 expression respectively (P < 0.05).Conclusion The decreased expression levels of serum miR-335 and miR-497 in colorectal cancer patients were correlated with the occurrence, development, deterioration, and poor prognosis of colorectal cancer. |
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| Keywords: | colorectal neoplasms microrna 335 microrna 497 clinicopathological features prognosis |
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