Metabolic control and periodontal treatment decreases elevated oxidative stress in the early phases of type 1 diabetes onset |
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| Institution: | 1. Division of Periodontology, Malatya Oral and Dental Health Hospital, The Turkish Ministry of Health, Malatya, Turkey;2. Division of Pediatric Endocrinology, Dr. Behçet Uz Children’s Hospital, İzmir, Turkey;3. Division of Pediatric Dentistry, Private Practice, İzmir, Turkey;1. Department of Orthodontics, Center of Dento-Maxillo-Facial Medicine, University of Bonn, Bonn, Germany;2. Department of Prosthodontics, Center of Dento-Maxillo-Facial Medicine, University of Bonn, Bonn, Germany;3. Oral Technology, University of Bonn, Bonn, Germany;4. Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Bonn, Germany;5. Oral Cell Biology Group, Department of Periodontology, Operative and Preventive Dentistry, University of Bonn, Bonn, Germany;1. Ex Junior Resident, Unit of Oral & Maxillofacial Surgery, Oral Health Sciences Centre, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India;2. Professor, Unit of Oral & Maxillofacial Surgery, Oral Health Sciences Centre, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India;3. Assistant Professor, Unit of Oral & Maxillofacial Surgery, Oral Health Sciences Centre, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India;1. Université de Ghardaïa, BP 455, route de l’aéroport, Ghardaïa, 47000, Algeria;2. Unité de Recherche Appliquée en Energies Renouvelables, URAER, Centre de Développement des Energies Renouvelables, CDER, 47133, Ghardaïa, Algeria;3. University of Tlemcen, BP. 119, Tlemcen R.p. 13000 Algeria;1. Department of Physics, Ataturk University, 25240 Erzurum, Turkey;2. Ostim Vocational School, Gazi University, 06500 Ankara, Turkey;3. Department of Biology, Ataturk University, 25240 Erzurum, Turkey;4. Department of Physics, K.K. Education Faculty, Ataturk University, 25240 Erzurum, Turkey |
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| Abstract: | ObjectiveRecently, increasing concern has been focused on the contribution of oxidative stress in the pathology of periodontal disease and diabetes mellitus. Firstly, the present study aimed to analyze gingival crevicular fluid (GCF), salivary, and serum oxidative status in children with type 1 diabetes mellitus (T1DM) at diagnosis and systemically healthy children with and without gingivitis. Additionally, the diabetic patients were reevaluated after diabetes and periodontal treatment.DesignThe study groups were composed of 32 T1DM patients at diagnosis, and age- and gender-matched thirty-six systemically healthy children with (G) and without (H) gingivitis. The diabetic patients who took insulin therapy (1.5 units/kg/day totally) and periodontal treatment (oral hygiene education with professional scaling) were reevaluated after 3 months. The levels of total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were recorded.ResultsGCF, salivary, and serum OSI were elevated in group T1DM compared to the other groups at baseline (p < 0.05), and decreased in group T1DM at reevaluation compared to baseline (p < 0.05). GCF OSI was positively correlated with periodontal clinical parameters (p < 0.05). Glycated hemoglobin was positively correlated with GCF TOS (r = 0.302, p = 0.007), GCF OSI (r = 0.346, p = 0.002), salivary TOS (r = 0.326, p = 0.046), and serum TOS (r = 0.239, p = 0.044).ConclusionThe instability in the oxidative status that accompanies diabetes may be considered a significant pathogenic factor of diabetes-related periodontal inflammation. |
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| Keywords: | Type 1 diabetes mellitus Gingivitis Gingival crevicular fluid Saliva Serum Oxidative stress |
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