脂氧酶12启动子区多态与食管鳞癌发病风险

目的本研究旨在探讨位于LOX12基因启动子区的-183G〉A单核苷酸多态与食管鳞癌发病风险之间的关系。方法以聚合酶链反应-限制性片段长度多态分析方法,检测了119个食管癌患者和119个无肿瘤正常对照的基因型。以logistic多因素回归模型计算各基因型的食管癌风险。结果 LOX12-183 GA基因型患食管鳞癌的风险比-183 GG基因型高约1倍（OR=1.93;95%CI=1.01-3.50;P=0.02）。LOX12-183纯合AA基因型携带者患食管鳞癌的风险比携带纯合GG基因型者高1.68倍（OR=2.68,95%CI=1.33-5.65;P〈0.01）。LOX12-G〉A多态和食管癌发病风险之间存在剂量反应效应。结论 LOX12启动子区-183G〉A变异是食管癌的重要遗传易感因素,在食管鳞癌的发生发展中发挥着重要的作用。

LOX12 promoter polymorphism and the risk of esophageal cancer

Objective This study sought to identified LOX12 promoter-183 GA polymorphism＇s effect on risk of developing esophageal squamous cell carcinoma（ESCC）.Methods One hundred and ninteen cases with ESCC and 119 cancer-free controls were genotyped for the LOX12-183 polymorphism by PCR-RFLP methods.The odds ratios（ORs） and 95% confidence intervals（CIs） were calculated using unconditional logistic regression model.All statistical tests were two-sided.Results It was found that subjects having the-183 AG genotype had an odds ratio（OR） of 1.93,95% CI（1.01-3.50;P=0.02） and-183 AA genotype had an odds ratio（OR） of 2.68,95% CI（1.33-5.65;P0.01） compared with those having the GG genotype.This-183 GA polymorphism effects on the development of the ESCC in a dose-response manner.Conclusion The LOX-183 GA polymorphism plays an important role in the development of ESCC cance.