甲磺酸罗哌卡因与盐酸罗哌卡因用于分娩镇痛的比较

目的比较甲磺酸罗哌卡因与盐酸罗哌卡因用于分娩镇痛的有效性和安全性。方法选在南通大学附属泰州人民医院2009年1月至2010年1月间主动要求行分娩镇痛、健康、单胎、足月临产初产妇100例随机分成甲磺酸罗哌卡因组与盐酸罗哌卡因组。采用视觉模拟疼痛评分(VAS),记录两组疼痛程度、产程时间、分娩方式、新生儿Apgar评分、运动神经阻滞评分(MBS)及不良反应情况。结果在疼痛程度、产程时间、分娩方式、新生儿Apgar评分、运动神经阻滞评分(MBS)以及不良反应方面,甲磺酸罗哌卡因与盐酸罗哌卡因未见明显的差异(P>0.05)。结论甲磺酸罗哌卡因与盐酸罗哌卡因应用于分娩镇痛,具有相似的有效性和安全性。

Comparison of Ropivacaine Mesylate and Ropivacaine Hydrochloride for Labour Analgesia

Objective To compare the efficacy and safety of ropivacaine mesylate and ropivacaine hydrochloride in labour analgesia. Methods From January in 2009 to January in 2010 in Taizhou People＇s Hospital of Nantong University, 100 patients of epidural analgesia in labor, health, single fetal and the term of the provisional maternal were enrolled and divided randomly into 2 groups： ropivacaine mesylate group and ropivacaine hydrochloride group. Then visual analogue scales （VAS）, the time of labor course, the pain of childbirth, mode of delivery, motor nerve block and other indicators were observed and compared between two groups. Results There were no significant differences between two groups on visual analogue scales, the time of labor course, the pain of childbirth, mode of delivery, motor nerve block and other indicators. Conclusion In labour analgesia, ropivacaine hydrochloride CEA and ropivacaine mesylate CEA possess proximal efficacy and safety.