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慢性乙型重型肝炎免疫学指标分析
引用本文:李秋伟,雷金艳,贾建伟,唐克诚,李谦,曹武奎,李顺天.慢性乙型重型肝炎免疫学指标分析[J].传染病信息,2010,23(5):285-286,290.
作者姓名:李秋伟  雷金艳  贾建伟  唐克诚  李谦  曹武奎  李顺天
作者单位:天津市肝病研究所,天津市传染病医院中西医结合1科,300192;天津中医药大学研究生院,300193
基金项目:国家"十一五"科技重大专项 
摘    要:目的探讨慢性乙型重型肝炎免疫学指标变化的规律及其与近期疗效的关系。方法对65例慢性乙型重型肝炎和15例健康体检人群分别采用流式细胞仪、快速免疫消浊比浊法进行外周血T淋巴细胞亚群、IgG、总补体溶血活性CH50(CH50)、补体C3(C3)的检测。结果慢性乙型重型肝炎CD3+、CD4+T淋巴细胞计数均低于正常组,晚期低于早、中期(P〈0.05),CD4+/CD8+比值高于正常组,晚期高于早、中期(P〈0.05)。IgG明显高于正常组,且晚期较早、中期进一步升高(P〈0.05),CH50、C3低于正常组,晚期低于早期(P〈0.05)。结论慢性乙型重型肝炎患者存在免疫功能紊乱,可能存在细胞免疫功能低下与体液免疫功能亢进,随着疾病进展其有加重趋势。

关 键 词:肝炎  乙型  慢性  T-淋巴细胞亚群  免疫

Immunological parameters in patients with chronic severe hepatitis B
LI Qiu-wei,LEI Jin-yan,JIA Jian-wei,TANG Ke-cheng,LI Qian,CAO Wu-kui,LI Shun-tian.Immunological parameters in patients with chronic severe hepatitis B[J].Infectious Disease Information,2010,23(5):285-286,290.
Authors:LI Qiu-wei  LEI Jin-yan  JIA Jian-wei  TANG Ke-cheng  LI Qian  CAO Wu-kui  LI Shun-tian
Institution:LI Qiu-wei,LEI Jin-yan,JIA Jian-wei*,TANG Ke-cheng,LI Qian,CAO Wu-kui,LI Shun-tian Department 1 of Integrated TCM , Western Medicine,Tianjin Infectious Diseases Hospital,Tianjin Institute of Liver Diseases,Tianjin 300192,China
Abstract:Objective To investigate the changes in the immunological parameters in patients with chronic severe hepatitis B and the relationship with therapeutic efficacy in the near future.Methods Flow cytometry and immunoturbidimetry were used to determine T lymphocyte subsets in peripheral blood,immunoglobulin G(IgG),50% complement hemolytic activity(CH50) and complement 3(C3) in 65 patients with chronic severe hepatitis B(severe hepatitis group) and 15 healthy controls(normal group).Results CD3+ and CD4+ T lymphoc...
Keywords:hepatitis B  chronic  T-lymphocyte subsets  immune  
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