| 脾约丸微生物限度检查方法的验证 |
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| 引用本文： | 林晓辉,张雪原,黄冬梅. 脾约丸微生物限度检查方法的验证[J]. 海峡药学, 2009, 21(1): 51-52 |
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| 作者姓名： | 林晓辉 张雪原 黄冬梅 |
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| 作者单位： | 广东省潮州市药品检验所,潮州,521000;广东省潮州市药品检验所,潮州,521000;广东省潮州市药品检验所,潮州,521000 |
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| 摘 要： | 目的建立脾约丸的微生物限度检查方法。方法通过测定5个规定试验菌种的回收率来确定其抑菌活性。结果该品种对金黄色葡萄球菌和枯草杆菌有抑菌活性，细菌计数采用离心沉淀集菌和培养基稀释联用的方法。结论用该法进行微生物限度检查，可以客观地反映药物中微生物的污染状况．可行性强，能达到检测目的。
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| 关 键 词： | 脾约丸 微生物限度检查法 验证 |
Verification of microbial limit test method for Piyue pills |
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| LIN Xiao-hui,ZHANG Xue-yuan,HUANG Dong-mei. Verification of microbial limit test method for Piyue pills[J]. Strait Pharmaceutical Journal, 2009, 21(1): 51-52 |
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| Authors: | LIN Xiao-hui ZHANG Xue-yuan HUANG Dong-mei |
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| Affiliation: | (Chaozhou Institute for Drug Control, Chaozhou 521000, China) |
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| Abstract: | OBJECTIVE To establish a method to determine the microbial limit test for Piyue pills.METHODS The antimicrobial effect of Piyue pills was determined by recovery rate with 5 control trains. RESULTS It had antibacterial effect on Staphylococcus aureus and Bacillus subtilis. Counting bacteria using a comprehensive method（deposit centrifugal method ＋ culture medium dilution method）.CONCLUSION The method is simple, fessible and accurate. |
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| Keywords: | Piyue pills Microbial limit test Methodology Validation |
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