异丙酚和安氟醚麻醉对硝酸甘油控制性降压的影响

目的 :评价异丙酚麻醉对硝酸甘油控制性降压的影响。方法 :2 0例口腔颌面部择期手术病人随机分为两组。Ⅰ组吸入安氟醚维持麻醉 ;Ⅱ组用微量泵持续输入异丙酚维持麻醉。以 0 .0 1%硝酸甘油溶液使MAP降低30 %。结果 :Ⅱ组血压易于下降和维持 ,停止降压后MAP显著低于Ⅰ组 (P <0 .0 5 ) ,HR明显慢于Ⅰ组 (P <0 .0 1) ;硝酸甘油平均剂量显著低于Ⅰ组 (P <0 .0 1) ,硝酸甘油总量较Ⅰ组减少 4 0 % ;两组围术期尿量差异无显著性。结论 :异丙酚维持麻醉可增强硝酸甘油控制性降压效果 ,减少并发症发生

Effects of Propofol or Enflurane Anesthesia on Nitroglycerine-Induced Hypotension

Objective: To evaluate the effect of propofol anesthesia on hemodynamic changes and dose requirement of nitroglycerine (NG) during NG induced hypotension. Methods: Twenty adult patients undergoing oral and maxillofacial surgery were randomly divieded into two groups. Anesthesia was maintained with inhalation of enflurane(group Ⅰ) or intravenou infusion of propofol(group Ⅱ).The MAP of both groups was reduced by 30% with continuous infusion of 0.01% NG solution. Results: Blood pressure was more easily reduced and maintained in group Ⅱ. The MAP and HR was lower in group Ⅱ than that in group Ⅰ after discontinuing of NG (P<0.05). The total dose of NG in group Ⅱ was 40% less than that in group Ⅰ. There was no significant difference in urinary output during operation between both groups. Conclusion: Propofol anesthesia can enforce the hypotensive effect of NG and reduce the dose requirement of NG and the incidencen of its complication.