Pharmacological inhibition of mitochondrial membrane permeabilization for neuroprotection |
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| Authors: | Toshio Hisatomi Tatsuro Ishibashi Joan W. Miller Guido Kroemer |
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| Affiliation: | aDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;bAngiogenesis Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA;cINSERM, U848, Villejuif, France;dInstitut Gustave Roussy, Villejuif, France;eUniversity Paris-Sud, Paris 11, Villejuif, France |
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| Abstract: | Recent data have provided important clues about the molecular mechanisms underlying certain neurodegenerative diseases. Most cell death in vertebrates proceeds via the mitochondrial pathway of apoptosis. Mitochondria contain proapoptotic factors such as cytochrome c and AIF in their intermembrane space. Furthermore, mitochondrial membrane permeabilization (MMP) is a critical event during apoptosis, representing the “point of no return” of the lethal process. Modern medicine is developing an increasing number of drugs for neurodegenerative disease, but no neuroprotective treatment has yet been established. While current treatments temporarily alleviate symptoms, they do not halt disease progression. This paper briefly reviews the pharmacological inhibition of mitochondrial membrane permeabilization for neuroprotection. |
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| Keywords: | Apoptosis Mitochondria membrane permeabilization Caspase AIF Apaf-1 Cytochrome c Retina |
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