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Specific allergen-induced Epstein-Barr nuclear antigen-positive B cells from patients with chronic-active Epstein-Barr virus infections |
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| Authors: | G B Olson M N Kanaan L M Kelley J F Jones |
| Affiliation: | 1. Division of Rheumatology and Immunology, Department of Medicine, Duke University Medical Center, Durham, NC, USA;2. Medical Research Service, VA Medical Center, Durham, NC, USA;1. Institute of Virology, Vaccines and Sera "Torlak", Belgrade, Serbia;2. University of Belgrade-Faculty of Pharmacy, Department of Microbiology and Immunology, Belgrade, Serbia;3. University of Belgrade-Faculty of Pharmacy, Department of Pathobiology, Belgrade, Serbia |
| Abstract: | Enriched B cells and peripheral blood lymphocytes from patients with chronic-active Epstein-Barr virus (CA-EBV) infections and subjects with mild and moderate allergies were cultured in vitro with specific allergens known to cause allergic reactions. A significant increase in Epstein-Barr nuclear antigen+ cells occurred only in the B cells obtained from patients with CA-EBV when cells were stimulated with the specific antigen. Results indicate an association between EBV-transformed cells and B cells with idiotypic expressions and may help to explain the association between CA-EBV and allergy in these patients. |
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