| 治疗慢性肝病的新药:辛伐他汀* |
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| 引用本文： | 毕再鸿,韩白乙拉,王炳元. 治疗慢性肝病的新药:辛伐他汀*[J]. 实用肝脏病杂志, 2021, 24(4): 603-606. DOI: 10.3969/j.issn.1672-5069.2021.04.038 |
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| 作者姓名： | 毕再鸿 韩白乙拉 王炳元 |
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| 作者单位： | 028000 内蒙古自治区通辽市传染病医院(毕再鸿,韩白乙拉);中国医科大学附属第一医院消化内科(王炳元) |
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| 基金项目： | *佑安肝病感染病专科医疗联盟科研课题(编号:LM202009) |
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| 摘 要： | 目的 辛伐他汀除了具有降脂特性外,还具有抗氧化、抗增殖和抗炎等多种功能,同时能改善内皮细胞功能和刺激新生血管生成,临床上很少出现明显的急性肝损伤副作用,为慢性肝病的治疗提供了一个新的选择。本文简要介绍了辛伐他汀治疗慢性肝病的基础和临床研究现状。
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| 关 键 词： | 慢性肝病 辛伐他汀 治疗 |
| 收稿时间： | 2020-12-29 |
Simvastatin: a newface for treatment of patients with chronic liver disease |
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| Bi Zaihong,Hanbai Yila,Wang Bingyuan. Simvastatin: a newface for treatment of patients with chronic liver disease[J]. Journal of Clinical Hepatology, 2021, 24(4): 603-606. DOI: 10.3969/j.issn.1672-5069.2021.04.038 |
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| Authors: | Bi Zaihong Hanbai Yila Wang Bingyuan |
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| Affiliation: | Department of Alcohol-related Liver Diseases, Infectious Disease Hospital, Tongliao 028000, Inner Mongolia Autonomous Region, China |
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| Abstract: | Objective Besides its lipid-lowering function, the simvastatin also exhibits multiple pleiotropic effects, such as antioxidative, antiproliferative and antiinflammatory properties, as well as the capacity to improve endothelial function and to stimulate neoangiogenesis. It rarely lead to apparent clinical acute liver injury, and might be a new choice for the treatment of patients with chronic liver diseases. In this article, we briefly introduce the basic and clinical researches of simvastatin in the treatment of patients with chronic liver diseases. |
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| Keywords: | Chronic liver diseases Simvastatin Therapy |
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