| 非酒精性脂肪性肝病动物模型研究进展* |
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| 引用本文： | 张译之,张晓慧,陈煜.非酒精性脂肪性肝病动物模型研究进展*[J].实用肝脏病杂志,2021,24(5):761-764. |
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| 作者姓名： | 张译之 张晓慧 陈煜 |
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| 作者单位： | 100069 北京市 首都医科大学附属北京佑安医院疑难肝病及人工肝中心/肝衰竭与人工肝治疗研究北京市重点实验室 |
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| 基金项目： | * 国家自然科学基金资助项目(编号:81500472);国家重点研发计划资助项目(编号:2017YFA0103000);国家科技重大专项“艾滋病和病毒性肝炎等重大传染病防治”专项基金资助项目(编号:2017ZX10203201-005/2017ZX10201201-001-001/2017ZX10201201-002-002/2017ZX10201201-004-002/2017ZX10202203-006-001/2017ZX10302201-004-002);北京市自然科学基金资助项目(编号:7202070);天晴肝病研究基金资助项目(编号:TQGB20200101);北京市医院管理局临床医学发展专项经费资助项目(编号:ZYLX201806) |
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| 摘 要： | 目的 非酒精性脂肪性肝病(NAFLD)发病率逐年增加,并可能发展成为终末期肝病。目前,仍缺乏针对该病的治疗药物,建立动物模型研究很有必要。尽管已有多种不同种类的疾病模型,但仍没有一种能真正反映人类整个疾病谱的代表性的NAFLD模型。本文对目前应用的NAFLD模型进行了综述,重点介绍动物模型、2D细胞模型和3D肝脏模型及其优缺点。
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| 关 键 词： | 非酒精性脂肪性肝病 细胞模型 动物模型 组织工程肝脏 |
| 收稿时间： | 2020-03-30 |
Models of nonalcoholic fatty liver disease |
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| Zhang Yizhi,Zhang Xiaohui,Chen Yu.Models of nonalcoholic fatty liver disease[J].Journal of Clinical Hepatology,2021,24(5):761-764. |
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| Authors: | Zhang Yizhi Zhang Xiaohui Chen Yu |
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| Institution: | Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment Research, Artificial Liver Center, You’an Hospital, Capital Medical University, Beijing 100069, China |
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| Abstract: | Objective The incidence rate of nonalcoholic fatty liver disease (NAFLD) is increasing. It might progress to the end-stage liver disease. However, there is still no specific treatment for this entity. Therefore, the establishment of representative animal models reflecting disease characteristics has become especially important. Although there are many different disease models, there is still a lack of NAFLD model which could cover the whole spectrum of this entity in human. In this paper, we reviewed the current progress on NAFLD model, focusing on animal model, 2D cell model, 3D liver model and their advantages and disadvantages. |
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| Keywords: | Nonalcoholic fatty liver disease Cell model Animal model Tissue engineering liver |
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