失代偿期肝硬化并发败血症患者外周血白细胞VCS参数变化及其临床价值分析

目的 探讨失代偿期肝硬化并发败血症患者外周血白细胞体积(V)、电导率(C)和散射(C)参数变化及其临床应用价值.方法 2017年6月～2020年6月我院诊治的失代偿期乙型肝炎肝硬化患者130例,其中发生败血症39例,普通感染组46例,未感染45例.使用COULTER LH 750/LH 755全自动血液分析仪检测外周血...

Implication of peripheral blood leukocyte VCS parameters in patients with decompensated liver cirrhosis and sepsis

Objective The aim of this study was to explore the implication of peripheral blood leukocyte volume (V), conductivity (C) and scattering (C) parameters in patients with decompensated liver cirrhosis and sepsis. Methods 130 patients with decompensated liver cirrhosis including complicated sepsis in 39, other common infection in 46 and non-infected in 45, were admitted to our hospital between June 2017 and June 2020. The mean neutrophil volume (MNV), mean neutrophil conductivity (MNC)and mean neutrophil scattering (MNS), mean monocyte volume (MMV), mean monocyte conductivity (MMC) and mean monocyte scattering (MMS), and mean lymphocyte volume (MLV), mean lymphocyte conductivity (MLC) and mean lymphocyte scattering (MLS) were detected. The receiver’s operating characteristic (ROC) was applied to evaluate the diagnostic efficacy of these indicators for sepsis occurrence. Results The neutrophil MNV and MNC were (149.5±9.8) and(148.6±9.6), both significantly higher than in infected or in non-infected patients; theMMV was (179.6±11.3), significantly higher than in infected or in non-infected patients; the MLV was (90.1±5.1), much higher than in infected or in non-infected patients; theROC analysis showed than the AUC of MNV, MMV, MLV, APACHE II and SOFA in diagnosing sepsis in cirrhotics were 0.756, 0.768, 0.681, 0.796 and 0.794, while the combination of the five reached to 0.847, having the best diagnostic efficacy (P<0.05). Conclusion The peripheral blood leukocyte VCS parameters have a good diagnostic efficacy for sepsis in patients with decompensated liver cirrhosis, which warrants further clinical investigation.