乙型肝炎肝硬化并发食管胃底静脉曲张破裂出血患者临床特征及其危险因素分析

目的 分析乙型肝炎肝硬化并发食管胃底静脉曲张破裂出血(EVB)患者的临床特征,并探讨乙型肝炎肝硬化发生EVB的危险因素.方法 2018年6月～2020年6月我院收治的乙型肝炎肝硬化并发食管胃底静脉曲张(GOV)患者108例,当发生曲张静脉破裂出血时,给予内科止血治疗.收集临床资料,应用单因素和多因素Logistic回归...

Clinical features and risk factors of esophagogastric variceal bleeding in patients with hepatitis B liver cirrhosis

Objective The aim of this study was to summarize the clinical features of patients with hepatitis B liver cirrhosis (LC) complicated by esophagogastric variceal bleeding (EVB), and to explore the risk factors of EVB. Methods The clinical data of 108 patients with hepatitis B LC complicated with gastroesophageal varices (GOV) were collected in our hospital between June 2018 and June 2020, and internal medicine was given when the EVB occurred. The clinical features of patients were summarized and the independent risk factors of EVB were evaluated by univariate and multivariate Logistic regression analysis. Results Among the 108 patients with hepatitis B LC and GOV, the EVB occurred in 38 cases (35.2%) , and out of which, 5 patients (13.2%) died within 72 hours after onset of bleeding; the univariate analysis indicated that overwork was not significantly related with EVB in patients with hepatitis B LC and GOV (P>0.05), while improper diet, taking non-steroidal anti-inflammatory agents, platelet (PLT) count, prothrombin time (PT), serum albumin (ALB), diameter of portal vein and splenic vein, red-color sign, Child-Pugh class of liver functions and GOV degrees were significantly correlated with EVB happening (P<0.05); the multivariate Logistic regression analysis showed that improper diet [OR(95%CI) : 2.2 (1.3-3.7)], increased portal vein diameter [OR(95% CI:1.4(1.1-1.7)], prolonged PT [OR(95% CI:1.3(1.1-1.6)], red-color sign [OR(95% CI:3.3(1.6-7.1)], Child-Pugh class C [OR(95% CI:3.9(1.7-9.0)] and severe GOV [OR(95% CI:3.5(1.9-6.5)] were the independent risk factors of EVB in patients with LC. Conclusion The EVB is the improper cause of gastrointestinal bleeding in patients with hepatitis B-induced LC,and the common intriguing events should be dealt with early and appropriately in clinical practice to decrease the EVB occurrence.